ArticlePflugers Archiv : European journal of physiology1993
Adaptation of rat extensor digitorum longus muscle to gamma irradiation and overload.
Article in Pflugers Archiv : European journal of physiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
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- Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training.The Journal of physiology · 2006Trial
- C-bouton components on rat extensor digitorum longus motoneurons are resistant to chronic functional overload.Journal of anatomy · 2022Article
- Contribution of muscle satellite cells to sarcopenia.Frontiers in physiology · 2022Review
- Regeneration competent satellite cell niches in rat engineered skeletal muscle.FASEB bioAdvances · 2019Article
- A novel in vitro model for the assessment of postnatal myonuclear accretion.Skeletal muscle · 2018Article
- The effects of dietary β-guanidinopropionic acid on growth and muscle fiber development in juvenile red porgy, Pagrus pagrus.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2018Article
- Starring or Supporting Role? Satellite Cells and Skeletal Muscle Fiber Size Regulation.Physiology (Bethesda, Md.) · 2018Review
- In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury.The Journal of physiology · 2017Article
- Genetic Evidence That Captured Retroviral Envelope syncytins Contribute to Myoblast Fusion and Muscle Sexual Dimorphism in Mice.PLoS genetics · 2016Article
- Satellite cell activity, without expansion, after nonhypertrophic stimuli.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Green tea extract attenuates muscle loss and improves muscle function during disuse, but fails to improve muscle recovery following unloading in aged rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Satellite cells in human skeletal muscle plasticity.Frontiers in physiology · 2015Review
- The effect of radiation dose on mouse skeletal muscle remodeling.Radiology and oncology · 2014Article
- Fibre type-specific satellite cell response to aerobic training in sedentary adults.The Journal of physiology · 2014Article
- The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men.Age (Dordrecht, Netherlands) · 2014Article
- Divergent modification of low-dose ⁵⁶Fe-particle and proton radiation on skeletal muscle.Radiation research · 2013Article
- Evidence for the contribution of muscle stem cells to nonhypertrophic skeletal muscle remodeling in humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Effective fiber hypertrophy in satellite cell-depleted skeletal muscle.Development (Cambridge, England) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The right extensor digitorum longus (EDL) muscle of growing male rats was overloaded by ablation of its synergist tibialis anterior (TA) muscle. Four weeks later, the overloaded muscle was heavier and contained larger type IIA, IIX and IIB fibres than either untreated contralateral muscle or control muscle from an untreated animal. The myonuclear-to-myoplasmic volume ratio was maintained in the overloaded muscle. Overloaded EDL muscle, previously subjected to a dose of irradiation sufficient to sterilise satellite cells, and EDL muscle which had been only irradiated, were significantly lighter and contained significantly smaller fibres than controls, though a significant amount of normal EDL muscle growth did occur following either treatment. The myonuclear-to-myoplasmic volume ratio of the irradiated muscles was smaller than in controls. Overloaded muscle, with or without prior irradiation, possessed a smaller proportion of fibres containing IIB myosin heavy chain (MHC) and a larger proportion of fibres containing IIA and IIX MHC; a significant percentage of these fibres coexpressed either type IIA and IIX MHC or type IIX and IIB MHC. Thus in the absence of satellite cell mitosis, muscles of young rats possess a limited capacity for normal growth but not for compensatory hypertrophy. Adaptations in MHC gene expression to chronic overload are completely independent of satellite cell activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.