ArticleMolecular and cellular biology1993
Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability.Oncogene · 2011Article
- RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis.BMC developmental biology · 2009Article
- A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.Molecular cancer · 2008Article
- Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb.Oncogene · 2001Article
- Functional analysis of carboxy-terminal deletion mutants of c-Myb.Journal of virology · 1999Article
- Transcriptional regulation by the carboxyl terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site.Oncogene · 1999Article
- Transformation by v-Myb.Oncogene · 1999Review
- D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain.The EMBO journal · 1998Article
- Apparent redundancy in myb gene function provides gearing for the control of flavonoid biosynthesis in antirrhinum flowers.The Plant cell · 1996Article
- FAETL motif required for leukemic transformation by v-Myb.Journal of virology · 1996Article
- A central role for a single c-Myb binding site in a thymic locus control region.Molecular and cellular biology · 1995Article
- Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.Journal of virology · 1995Article
- The carboxyterminus of human c-myb protein stimulates activated transcription in trans.Nucleic acids research · 1994Article
- Oncogenic truncation of the first repeat of c-Myb decreases DNA binding in vitro and in vivo.Molecular and cellular biology · 1993Article
- Individual repeats of Drosophila Myb can function in transformation by v-Myb.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The v-myb oncogene and its cellular homolog c-myb encode sequence-specific DNA-binding proteins which regulate transcription from promoters containing Myb-binding sites in animal cells. We have developed a Saccharomyces cerevisiae system to assay transcriptional activation by v-Myb and c-Myb. In yeast strains containing integrated reporter genes, activation was strictly dependent upon both the Myb DNA-binding domain and the Myb recognition element. BAS1, an endogenous Myb-related yeast protein, was not required for transactivation by animal Myb proteins and by itself had no detectable effect on a Myb reporter gene. Deletion analyses demonstrated that a domain of v-Myb C terminal to the previously mapped Myb transcriptional activation domain was required for transactivation in animal cells but not in S. cerevisiae. The same domain is also required for the efficient transformation of myeloid cells by v-Myb. In contrast to results in animal cells, in S. cerevisiae the full-length c-Myb was a much stronger transactivator than a protein bearing the oncogenic N- and C-terminal truncations of v-Myb. These results imply that negative regulation of c-Myb by its own termini requires an additional animal cell protein or small molecule that is not present in S. cerevisiae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.