ArticleMolecular and cellular biology1993
In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.
Article in Molecular and cellular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 89 citations in OpenAlex.
- Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation.Journal of virology · 2001Article
- Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.The EMBO journal · 2000Article
- Regulation of STAT1 nuclear export by Jak1.Molecular and cellular biology · 2000Article
- Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.Molecular and cellular biology · 1999Article
- A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Receptor-associated constitutive protein tyrosine phosphatase activity controls the kinase function of JAK1.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.The EMBO journal · 1996Article
- Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents.The EMBO journal · 1996Article
- Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.Molecular and cellular biology · 1996Article
- Inhibition of alpha interferon but not gamma interferon signal transduction by phorbol esters is mediated by a tyrosine phosphatase.Molecular and cellular biology · 1996Article
- Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.Molecular and cellular biology · 1995Article
- Ligand-dependent and -independent activation of the transcription factor gamma RF-1 in a cell-free system.The Biochemical journal · 1995Article
- Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.The EMBO journal · 1994Article
- Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.Journal of virology · 1994Article
- Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.Molecular and cellular biology · 1994Article
- Prolactin activates the interferon-regulated p91 transcription factor and the Jak2 kinase by tyrosine phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Inhibitors of serine/threonine phosphatases enhance phosphorylation of the interferon-gamma receptor while selectively attenuating interferon-gamma-induced gene expression in human peripheral-blood monocytes.The Biochemical journal · 1994Article
- Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).The EMBO journal · 1994Article
- Growth hormone and erythropoietin differentially activate DNA-binding proteins by tyrosine phosphorylation.Molecular and cellular biology · 1994Article
- A unique palindromic element mediates gamma interferon induction of mig gene expression.Molecular and cellular biology · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma interferon (IFN-gamma) activates the formation of a DNA-binding protein complex (FcRF gamma) that recognizes the gamma response region (GRR) of the promoter for the human high-affinity Fc gamma receptor. In a membrane-enriched fraction prepared from human peripheral blood monocytes, IFN-gamma activation of FcRF gamma occurred within 1 min and was ATP dependent. Activation of FcRF gamma required a tyrosine kinase activity, and recognition of the GRR sequence by FcRF gamma could be abrogated by treatment with a tyrosine-specific protein phosphatase. Treatment of cells with vanadate alone resulted in the formation of FcRF gamma without the need for IFN-gamma. UV cross-linking and antibody competition experiments demonstrated that the FcRF gamma complex was composed of at least two components: the 91-kDa protein of the IFN-alpha-induced transcription complex ISGF3 and a 43-kDa component that bound directly to the GRR. Therefore, specificity for IFN-induced transcriptional activation of early response genes requires at least two events: (i) ligand-induced activation of membrane-associated protein by tyrosine phosphorylation and (ii) formation of a complex composed of an activated membrane protein(s) and a sequence-specific DNA-binding component.
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