ArticleThe Journal of cell biology1993
The roles of the rod end and the tail in vimentin IF assembly and IF network formation.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.Soft matter · 2024Article
- Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly.International journal of molecular sciences · 2022Article
- Genetically Engineered Lung Cancer Cells for Analyzing Epithelial-Mesenchymal Transition.Cells · 2019Article
- Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division.Nature communications · 2019Article
- Electron paramagnetic resonance analysis of the vimentin tail domain reveals points of order in a largely disordered region and conformational adaptation upon filament assembly.Protein science : a publication of the Protein Society · 2013Article
- Identification of phosphorylation-induced changes in vimentin intermediate filaments by site-directed spin labeling and electron paramagnetic resonance.Biochemistry · 2008Article
- Glial fibrillary acidic protein filaments can tolerate the incorporation of assembly-compromised GFAP-delta, but with consequences for filament organization and alphaB-crystallin association.Molecular biology of the cell · 2008Article
- Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cells.Cancer research · 2008Article
- Identifying the role of specific motifs in the lens fiber cell specific intermediate filament phakosin.Investigative ophthalmology & visual science · 2007Article
- The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27.American journal of human genetics · 2006Article
- Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly.The EMBO journal · 2002Article
- A dysfunctional desmin mutation in a patient with severe generalized myopathy.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation.The Journal of cell biology · 1998Article
- Intermediate filaments as dynamic structures.Cancer metastasis reviews · 1996Review
- The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.The Journal of cell biology · 1995Article
- Determinants for intracellular sorting of cytoplasmic and nuclear intermediate filaments.The Journal of cell biology · 1994Article
- Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.The Journal of cell biology · 1994Article
- The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation.The Journal of cell biology · 1993Article
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Authors and funding
4 authors.
Funding
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Abstract
Using mutagenesis, we investigated the importance of two vimentin domains: (a) a highly conserved segment near the carboxy end of the alpha-helical rod, and (b) the tail, with which the rod end is known to interact. As judged by in vitro filament assembly and expression in transiently transfected cells lacking an endogenous vimentin network, the rod-tail interaction is not essential for 10 nm filament structure in vitro or for formation of fibrous arrays in culture. However, when mutated, amino acid residues within the rod and the tail segments can cause perturbations in IF assembly and in IF network formation. Finally, our studies show that the vimentin tail seems to play a role both in thermodynamically stabilizing IF structure in vitro and in establishing proper IF networks in vivo.
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