ArticleJapanese journal of cancer research : Gann1993
Detection of active form of transforming growth factor-beta in cerebrospinal fluid of patients with glioma.
Article in Japanese journal of cancer research : Gann, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells.The Journal of clinical investigation · 2021Article
- Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models.Molecular cancer therapeutics · 2016Article
- Cytokines: shifting the balance between glioma cells and tumor microenvironment after irradiation.Journal of cancer research and clinical oncology · 2015Review
- Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression.Current pathobiology reports · 2013Article
- Challenges in clinical design of immunotherapy trials for malignant glioma.Neurosurgery clinics of North America · 2010Review
- Increased concentrations of transforming growth factor beta1 and beta2 in the plasma of patients with glioblastoma.Journal of neuro-oncology · 2006Article
- Increased expression of TGF-beta1 reduces tumor growth of human U-87 Glioblastoma Cells in vivo.Cancer immunology, immunotherapy : CII · 2006Article
- Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.The Journal of clinical investigation · 1994Article
- Tumor invasion, proteolysis, and angiogenesis.Journal of neuro-oncology · 1994Review
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Authors and funding
3 authors.
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Abstract
We examined transforming growth factor-beta (TGF-beta) activity in cerebrospinal fluid of 39 patients with various brain tumors, and found it in 10 glioma cases that had lesions related to subarachnoid space or ventricle. In one glioma case, TGF-beta detected on admission disappeared after radiation and chemotherapy. We confirmed that five glioma cell lines produced TGF-beta, and that four of them produced active form of TGF-beta directly. The active form of TGF-beta was also identified from cerebrospinal fluid before the acidification treatment in two cases. The calculated contents were 110 ng/ml and 18 ng/ml. These results indicate that active form of TGF-beta is directly produced by tumor cells in patients with glioma, and may contribute to immunodeficiency of the host.
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