ArticleImmunogenetics1993
Complete cDNA sequence of a rainbow trout IgM gene and evolution of vertebrate IgM constant domains.
Article in Immunogenetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 61 citations in OpenAlex.
- Immunoglobulins: Mechanistic Approaches in Moderation of Various Inflammatory and Anti-inflammatory Pathways.Current pharmaceutical biotechnology · 2025Review
- Standardized IMGT® Nomenclature of Salmonidae IGH Genes, the Paradigm of Atlantic Salmon and Rainbow Trout: From Genomics to Repertoires.Frontiers in immunology · 2019Article
- Perspective on the Development and Validation of Ab Reagents to Fish Immune Proteins for the Correct Assessment of Immune Function.Frontiers in immunology · 2018Article
- A Review of Intra- and Extracellular Antigen Delivery Systems for Virus Vaccines of Finfish.Journal of immunology research · 2015Review
- The up-regulation of large yellow croaker secretory IgM heavy chain at early phase of immune response.Fish physiology and biochemistry · 2010Article
- Molecular and cellular analysis of B-cell populations in the rainbow trout using Pax5 and immunoglobulin markers.Developmental and comparative immunology · 2008Article
- "A Japanese gentleman of the Samurai tradition": Takeshi Matsunaga 1945-2003.Immunogenetics · 2003Article
- Unified nomenclature of Ig VH genes in rainbow trout (Oncorhynchus mykiss): definition of eleven VH families.Immunogenetics · 1996Article
- Article
- Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.Immunogenetics · 1995Article
- The immunoglobulin repertoire of the rainbow trout (Oncorhynchus mykiss): definition of nine Igh-V families.Immunogenetics · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A complete cDNA clone encoding secreted IgM molecules was isolated from a spleen cDNA library of rainbow trout (Oncorhynchus mykiss). It encodes the leader peptide, VH, DH, JH, and the whole constant region of the secreted IgM molecule. We also studied the copy number of the IgM gene and an unusual RNA splicing mechanism which generates membrane IgM lacking the CH4 domain in rainbow trout. Amino acid sequence comparison of IgM protein sequences from this fish and other vertebrates indicates that some domains of IgM have evolved at a relatively constant rate. The evolution of salmonid fish including divergence time is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.