ArticleBritish journal of cancer1993
Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
Article in British journal of cancer, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
- Wnt/β-catenin signaling in cancers and targeted therapies.Signal transduction and targeted therapy · 2021Review
- Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.Oncogene · 2017Article
- CpG methylation of APC promoter 1A in sporadic and familial breast cancer patients.Cancer biomarkers : section A of Disease markers · 2017Article
- Review
- Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function.Neoplasia (New York, N.Y.) · 2012Article
- Navigating breast cancer: axon guidance molecules as breast cancer tumor suppressors and oncogenes.Journal of mammary gland biology and neoplasia · 2011Review
- Key signaling nodes in mammary gland development and cancer: β-catenin.Breast cancer research : BCR · 2010Review
- Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype.British journal of cancer · 2008Article
- Wnt-cadherin connections in normal and neoplastic mammary epithelium.Journal of mammary gland biology and neoplasia · 2003Review
- Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.Oncogene · 2002Article
- Loss of DCC expression in astrocytomas: relation to p53 abnormalities, cell kinetics, and survival.Journal of clinical pathology · 2001Article
- Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers.British journal of cancer · 2001Article
- Association of the I1307K APC mutation with hereditary and sporadic breast/ovarian cancer: more questions than answers.British journal of cancer · 2000Article
- Somatic mutations of the APC gene in primary breast cancers.The American journal of pathology · 2000Article
- Article
- The effect of the I1307K APC polymorphism on the clinicopathological features and natural history of breast cancer.British journal of cancer · 1999Article
- Mapping of a breast cancer tumor suppressor gene locus to a 4-cM interval on chromosome 18q21.Japanese journal of cancer research : Gann · 1997Article
- Frequent reduction or loss of DCC gene expression in human osteosarcoma.British journal of cancer · 1997Article
- Molecular and cellular biomarkers for field cancerization and multistep process in head and neck tumorigenesis.Cancer metastasis reviews · 1996Review
- Decreased expression of the DCC gene in human breast carcinoma.Surgery today · 1996Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared with allele loss at 17p13 and concurrent LOH at two or more of the loci was noted in 24% of tumours. Expression of a 12 kb DCC mRNA was demonstrated in 14/34 (42%) of the cancers and in all five tumours with LOH at the DCC locus there was an additional 11 kb DCC mRNA. Abnormalities of three loci involved in colorectal cancer (5q21, 17p13 and 18q21) therefore also occur in sporadic breast cancer. The accumulation of such genetic abnormalities may confer a growth advantage important in the development of breast cancer.
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