ArticleGut1993
Altered glycosylation of integrin adhesion molecules in colorectal cancer cells and decreased adhesion to the extracellular matrix.
Article in Gut, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Interplay of integrins and selectins in metastasis.Molecular oncology · 2025Review
- Central Role of β-1,4-GalT-V in Cancer Signaling, Inflammation, and Other Disease-Centric Pathways.International journal of molecular sciences · 2023Review
- A signature based on glycosyltransferase genes provides a promising tool for the prediction of prognosis and immunotherapy responsiveness in ovarian cancer.Journal of ovarian research · 2023Article
- Physiological Cues Involved in the Regulation of Adhesion Mechanisms in Hematopoietic Stem Cell Fate Decision.Frontiers in cell and developmental biology · 2020Review
- Overview of the Muscle Cytoskeleton.Comprehensive Physiology · 2017Review
- Distinct ErbB2 receptor populations differentially interact with beta1 integrin in breast cancer cell models.PloS one · 2017Article
- Noninvasive detection of gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- N-glycosylation regulates ADAM8 processing and activation.The Journal of biological chemistry · 2014Article
- Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination.TheScientificWorldJournal · 2014Article
- RETRACTED ARTICLE: Expression of integrin genes and proteins in progression and dissemination of colorectal adenocarcinoma.BMC clinical pathology · 2013Article
- Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen.Biology open · 2013Article
- L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer.Journal of cellular and molecular medicine · 2012Article
- Colorectal cancer in the cotton top tamarin (Saguinus oedipus): how do they evade liver metastasis?Digestive diseases and sciences · 2011Article
- Integrin alpha6 cleavage: a novel modification to modulate cell migration.Experimental cell research · 2007Article
- Regulation of trophoblast beta1-integrin expression by contact with endothelial cells.Cell communication and signaling : CCS · 2004Article
- Ras oncogene directs expression of a differentially sialylated, functionally altered beta1 integrin.Oncogene · 2003Article
- Mechanisms of colon cancer binding to substratum and cells.Digestive diseases and sciences · 1996Article
- Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.British journal of cancer · 1996Article
- Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells.Clinical & experimental metastasis · 1995Article
- A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer.British journal of cancer · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrin mediated interactions between tumour cells and the surrounding extracellular matrix are thought to play crucial parts in the complex process of invasion and metastasis. It has been previously shown that the expression of integrins is differently diminished in a chain-specific manner in human colorectal cancer. To further characterise the integrins still expressed in colorectal carcinomas, immunoblots with monoclonal antibodies against the beta 1 integrin subunit have been performed. In isolated cell membranes of colorectal cancers a second smaller beta 1 chain (105 kD non-reduced) was found as well as the mature beta 1 chain (116 kD non-reduced) present in normal mucosa of the colon. This smaller beta 1 chain comigrates with the diminished glycosylated precursor form of the beta 1 chain. The role of N-glycosylation for the function and expression of integrins in vitro was therefore investigated, with deoxymannojirimycin (DMJ) and deoxynojirimycin (DNJ) as specific inhibitors of N-glycan processing. Pretreatment of human colon adenocarcinoma derived HT-29 cells with DMJ resulted in an expression of the 105 kD beta 1 precursor chain and of smaller forms of the alpha 1, alpha 3, alpha 6, and alpha v integrin subunits in a time and dose dependent manner. HT-29 cells treated with DMJ adhered poorly to laminin (8% of untreated controls), collagen type IV (40%), and fibronectin (35%). Pretreatment of the cells with DNJ did not alter the molecular weight of the integrin chains expressed and reduced HT-29 adhesion to laminin and fibronectin only to 68% and 49% respectively. Adhesion to collagen type IV was increased to 124% by DNJ. These results show that N-glycan processing is essential for the function and expression of integrins in human colorectal cancer cells. An altered glycosylation of these adhesion receptors may contribute to a more invasive or metastatic phenotype in colorectal cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.