ReviewEuropean journal of clinical pharmacology1993
An overview of glucocorticoid anti-inflammatory actions.
Review in European journal of clinical pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Can adjunctive corticosteroid therapy improve patient-centered outcomes following third molar surgery? A systematic review.Medicina oral, patologia oral y cirugia bucal · 2022Pooled it
- Interventions for hand eczema.The Cochrane database of systematic reviews · 2019Pooled it
- Effects of high-dose corticosteroids on post-traumatic inflammatory mediators.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Trial
- Non-type 2 airway inflammation in severe asthma: from bench to bedside.Frontiers in immunology · 2026Review
- Volumetric measurement of herniated disc material as a predictor of outcome in periradicular therapy.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Visual Outcomes and Safety Profile of "Dropless Vitrectomy" for Epiretinal Membranes.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Biomimetic optimization of silicone breast implant integration: insights into wound healing and the foreign body response.Frontiers in bioengineering and biotechnology · 2025Review
- Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support.BMJ open respiratory research · 2024Article
- NSAIDs between past and present; a long journey towards an ideal COX-2 inhibitor lead.RSC advances · 2024Review
- Progress in regulating inflammatory biomaterials for intervertebral disc regeneration.Bioactive materials · 2024Review
- Airway Epithelial-Derived Immune Mediators in COVID-19.Viruses · 2023Review
- The Role of the Stress Response in Metabolic Dysfunction-Associated Fatty Liver Disease: A Psychoneuroendocrineimmunology-Based Perspective.Nutrients · 2023Article
- Simultaneous Measurement of Cortisol, Cortisone, Dexamethasone and Additional Exogenous Corticosteroids by Rapid and Sensitive LC-MS/MS Analysis.Molecules (Basel, Switzerland) · 2022Article
- Functionalization of Silicone Surface with Drugs and Polymers for Regulation of Capsular Contracture.Polymers · 2021Review
- Silicone Breast Implant Coated with Triamcinolone Inhibited Breast-Implant-Induced Fibrosis in a Porcine Model.Materials (Basel, Switzerland) · 2021Article
- Turkish Guideline for Diagnosis and Treatment of Allergic Rhinitis (ART).Turkish archives of otorhinolaryngology · 2021Article
- A model of dopamine and serotonin-kynurenine metabolism in cortisolemia: Implications for depression.PLoS computational biology · 2021Article
- Molecular links between endocrine, nervous and immune system during chronic stress.Brain and behavior · 2021Review
- Ultrasound-Guided Triamcinolone Acetonide Hydrodissection for Carpal Tunnel Syndrome: A Randomized Controlled Trial.Frontiers in medicine · 2021Article
- Response Surface Optimization of Ultra-Elastic Nanovesicles Loaded with Deflazacort Tailored for Transdermal Delivery: Accentuated Bioavailability and Anti-Inflammatory Efficacy.International journal of nanomedicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids (GC) exert a variety of important anti-inflammatory actions. We have studied their effects in allergic inflammation and believe that their anti-allergic effects reflect their anti-inflammatory activities in general. These effects include inhibition of cytokine and other mediator secretion, inhibition of leucocyte priming in eosinophils and neutrophils, reduction of vascular permeability, inhibition of arachidonic acid metabolite and platelet activating factor (PAF) release, synergistic or permissive effects on responses to other mediators, such as catecholamines and other endogenous hormone-like molecules, and modulation of enzyme systems involved in inflammation. Glucocorticoid actions are thus multifaceted; this feature explains both their unequalled efficacy in inflammatory diseases and the difficulty in replacing them with other medications that have a uni-dimensional profile of action.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.