ArticleThe EMBO journal1994
A role for calnexin (IP90) in the assembly of class II MHC molecules.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- A multi-omics prognostic model of cuproptosis affects the prognosis of stomach adenocarcinoma.Clinical epigenetics · 2025Article
- Fucosylation of HLA-DRB1 regulates CD4Nature cancer · 2023Article
- Calnexin, More Than Just a Molecular Chaperone.Cells · 2023Review
- Intramembrane client recognition potentiates the chaperone functions of calnexin.The EMBO journal · 2022Article
- The Autophagy Receptor TAX1BP1 (T6BP) improves antigen presentation by MHC-II molecules.EMBO reports · 2022Article
- The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.BMC immunology · 2021Article
- Proteasomal degradation within endocytic organelles mediates antigen cross-presentation.The EMBO journal · 2019Article
- A personal retrospective on the mechanisms of antigen processing.Immunogenetics · 2019Review
- The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling.Frontiers in immunology · 2018Review
- Rainbow trout (Oncorhynchus mykiss) contain two calnexin genes which encode distinct proteins.Developmental and comparative immunology · 2014Article
- Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.Frontiers in immunology · 2013Review
- Regulation of CD20 in rituximab-resistant cell lines and B-cell non-Hodgkin lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Article
- Role of heat shock proteins in diseases and their therapeutic potential.Indian journal of microbiology · 2011Article
- Stoichiometry of HLA class II-invariant chain oligomers.PloS one · 2011Article
- Molecular characterization and expression analysis of MHC class II alpha and beta genes in large yellow croaker (Pseudosciaena crocea).Molecular biology reports · 2010Article
- Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b.The EMBO journal · 2006Article
- A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Association of intracellular proteins with folded major histocompatibility complex class I molecules.Immunologic research · 2004Review
- Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by loss of Ca2+ from the endoplasmic reticulum.The Biochemical journal · 2003Article
- Role of the C-terminal propeptide in the activity and maturation of gamma -interferon-inducible lysosomal thiol reductase (GILT).Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Major histocompatibility complex (MHC) class II antigens consist of alpha and beta chains that associate intracellularly with the invariant (I) chain. The HLA-DR alpha beta I complex assembles in the endoplasmic reticulum (ER) into a nonameric structure via progressive addition of three alpha beta dimers to a core invariant chain trimer. We have examined intracellular association of alpha beta I complexes with the resident ER protein calnexin. Calnexin associates rapidly (within 3 min) with newly synthesized alpha, beta and I chains, and remains associated with the assembling alpha beta I complex until the final alpha beta dimer is added, forming the complete nonamer. Dissociation of calnexin parallels egress of alpha beta I from the ER. These results suggest that calnexin retains and stabilizes both free class II subunits and partially assembled class II-I chain complexes until assembly of the nonamer is complete.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.