ArticleThe EMBO journal1994
Functional differences between mammalian transcription activation domains at the yeast GAL1 promoter.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Systematic discovery of novel eukaryotic transcriptional regulators using sequence homology independent prediction.BMC genomics · 2017Article
- Histone acetyltransferases in rice (Oryza sativa L.): phylogenetic analysis, subcellular localization and expression.BMC plant biology · 2012Article
- Role of the C-terminal domains of rice (Oryza sativa L.) bZIP proteins RF2a and RF2b in regulating transcription.The Biochemical journal · 2007Article
- Arabidopsis GLUTAMINE-RICH PROTEIN23 is essential for early embryogenesis and encodes a novel nuclear PPR motif protein that interacts with RNA polymerase II subunit III.The Plant cell · 2006Article
- Common effects of acidic activators on large-scale chromatin structure and transcription.Molecular and cellular biology · 2005Article
- Article
- Molecular characterization of AtNAM: a member of the Arabidopsis NAC domain superfamily.Plant molecular biology · 2002Article
- A functional screening assay for the isolation of transcription factors.Nucleic acids research · 2002Article
- The yeast protein Xtc1 functions as a direct transcriptional repressor.Nucleic acids research · 2002Article
- Article
- Conservation of glutamine-rich transactivation function between yeast and humans.Molecular and cellular biology · 2000Article
- An artificial transcriptional activating region with unusual properties.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The role of AHA motifs in the activator function of tomato heat stress transcription factors HsfA1 and HsfA2.The Plant cell · 2000Article
- Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling.Oncogene · 2000Article
- Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cohabitation of insulators and silencing elements in yeast subtelomeric regions.The EMBO journal · 1999Article
- TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB.The EMBO journal · 1998Article
- Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains.The Biochemical journal · 1998Article
- Conserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins.Journal of virology · 1997Article
- Three classes of mammalian transcription activation domain stimulate transcription in Schizosaccharomyces pombe.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have fused representatives of three structurally and functionally distinct classes of mammalian transcription activation domains for RNA polymerase II to the yeast GAL4 DNA binding domain. All fusion proteins were stable when expressed in yeast and were tested for their ability to activate transcription from various positions in the yeast GAL1 promoter. Activation domains functional from remote as well as TATA-proximal positions in mammalian cells, e.g. the acidic-type domain of VP16, also stimulate transcription in yeast from various promoter positions. Proline-rich domains, as e.g. in AP-2 and CTF/NF1, with considerable promoter activity and low enhancer activity in mammalian cells stimulate transcription in yeast only from a position close to the TATA box. The glutamine-rich domains of Oct1, Oct2 and Sp1, which activate transcription in mammalian cells from close to the TATA box in response to a remote enhancer, are inactive in the yeast GAL1 promoter. This finding might reflect some basic difference between the organization of yeast and mammalian promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.