ArticleThe EMBO journal1994
A common factor regulates both Th1- and Th2-specific cytokine gene expression.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 150 citations in OpenAlex.
- KCell communication and signaling : CCS · 2018Article
- Mycobacterium tuberculosis secretory proteins downregulate T cell activation by interfering with proximal and downstream T cell signalling events.BMC immunology · 2015Article
- Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases.Lipids in health and disease · 2012Article
- Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.Critical reviews in immunology · 2012Review
- Interleukin-10: new perspectives on an old cytokine.Immunological reviews · 2008Review
- Article
- Yin-Yang 1 regulates effector cytokine gene expression and T(H)2 immune responses.The Journal of allergy and clinical immunology · 2008Article
- Regulation of transcription factor NFAT by ADP-ribosylation.Molecular and cellular biology · 2008Article
- Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Decreased CD4 expression by polarized T helper 2 cells contributes to suboptimal TCR-induced phosphorylation and reduced Ca2+ signaling.European journal of immunology · 2005Article
- Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2004Article
- Nuclear factor of activated T cells c is a target of p38 mitogen-activated protein kinase in T cells.Molecular and cellular biology · 2003Article
- Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.The Journal of experimental medicine · 2002Article
- c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.The Journal of experimental medicine · 2002Article
- Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription.The Journal of cell biology · 2002Article
- TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937.Genes & development · 2001Article
- Molecular and cellular mechanisms of cardiotoxicity.Environmental health perspectives · 2001Review
- Activation of the IL-10 gene promoter following photodynamic therapy of murine keratinocytes.Photochemistry and photobiology · 2001Article
- Molecular regulation of cytokine gene expression during the immune response.Journal of clinical immunology · 1999Review
- Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Murine T helper cell clones are classified into two distinct subsets, T helper 1 (Th1) and T helper 2 (Th2), on the basis of cytokine secretion patterns. Th1 clones produce interleukin-2 (IL-2), tumor necrosis factor-beta (TNF-beta) and interferon-gamma (IFN-gamma), while Th2 clones produce IL-4, IL-5, IL-6 and IL-10. These subsets differentially promote delayed-type hypersensitivity or antibody responses, respectively. The nuclear factor NF-AT is induced in Th1 clones stimulated through the T cell receptor-CD3 complex, and is required for IL-2 gene induction. The NF-AT complex consists of two components: NF-ATp, which pre-exists in the cytosol and whose appearance in the nucleus is induced by an increase of intracellular calcium, and a nuclear AP-1 component whose induction is dependent upon activation of protein kinase C (PKC). Here we report that the induction of the Th2-specific IL-4 gene in an activated Th2 clone involves an NF-AT complex that consists only of NF-ATp, and not the AP-1 component. On the basis of binding experiments we show that this 'AP-1-less' NF-AT complex is specific for the IL-4 promoter and does not reflect the inability of activated Th2 cells to induce the AP-1 component. We propose that NF-ATp is a common regulatory factor for both Th1 and Th2 cytokine genes, and that the involvement of PKC-dependent factors, such as AP-1, may help determine Th1-/Th2-specific patterns of gene expression.
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