ArticleActa neuropathologica1993
Neuropathological findings in 224 patients with temporal lobe epilepsy.
Article in Acta neuropathologica, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 81 citations in OpenAlex.
- Surgical Treatment of Lesional Mesial Temporal Lobe Epilepsy.Journal of epilepsy research · 2018Review
- Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Frontal Lobe Epilepsy: A New Clinico-Pathological Entity.Brain pathology (Zurich, Switzerland) · 2017Article
- Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure-associated lesion.Brain pathology (Zurich, Switzerland) · 2013Article
- Microsurgical and tractographic anatomical study of insular and transsylvian transinsular approach.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2011Article
- Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy.NeuroImage · 2008Article
- Pathophysiologic characteristics of balloon cells in cortical dysplasia.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2008Article
- Clinical features and epileptogenesis of dysembryoplastic neuroepithelial tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2006Article
- Memory fMRI in left hippocampal sclerosis: optimizing the approach to predicting postsurgical memory.Neurology · 2006Article
- [11C]-Methionine PET: dysembryoplastic neuroepithelial tumours compared with other epileptogenic brain neoplasms.Journal of neurology, neurosurgery, and psychiatry · 2005Article
- Upregulation of glutamate receptors in rat cerebral cortex with neuronal migration disorders.Journal of Korean medical science · 2004Article
- Epileptogenesis in the Dysplastic Brain: A Revival of Familiar Themes.Epilepsy currents · 2001Article
- Predictors of outcome and pathological considerations in the surgical treatment of intractable epilepsy associated with temporal lobe lesions.Journal of neurology, neurosurgery, and psychiatry · 2001Article
- Dysembryoplastic neuroepithelial tumour of the cerebellum.Acta neuropathologica · 1995Article
- Post-Operative Seizure Freedom Need not be Elusive in Mild Oligodendroglial Hyperplasia and Epilepsy (MOGHE).Annals of Indian Academy of NeurologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the period between 1976 and 1990, 247 patients with pharmaco-resistant complex partial seizures and a documented unilateral epileptogenic area in the mediobasal temporal lobe underwent a selective amygdalo-hippocampectomy procedure at our institution. Biopsy specimens from 224 patients (91% of the total) were available for a retrospective histopathological and immunohistochemical review. The tissue specimens of 23 patients without evidence for a macroscopic lesion have been used for neurochemical studies and could not be evaluated histopathologically. The most common temporal lobe pathology were neoplasms in 126 patients, i.e. 56%. Tumor entities observed included 23 astrocytomas (18% of all tumors), 17 gangliogliomas (13%), 15 oligodendrogliomas (12%), 15 cases of glioblastoma multiforme (12%), 13 pilocytic astrocytomas (10%), 12 oligo-astrocytomas (10%), 11 anaplastic astrocytomas (9%) and 20 tumors of various other histologies. In 23 specimens (10%), small foci of oligodendroglia-like clear cells were found. The frequent association of these foci with low-grade gliomas or neural hamartomas raises the possibility that these structures may serve as precursor lesion for neuroepithelial tumors of the temporal lobe. In 98 cases, pathological changes of non-neoplastic origin were encountered. The most common diagnoses in this group included hippocampal gliosis/sclerosis (49 cases, 22%) and vascular malformations (20 cases, 9%). Hamartomas, i.e. focal accumulations of dysplastic neuro-glial cells were diagnosed in 14 patients (6%). In only four cases have we not been able to detect any microscopic pathology. These results indicate that a high proportion of pharmaco-therapy-resistant complex-partial seizures are caused by neoplasms of the temporal lobe, some of which appear to be strikingly overrepresented in this group of patients.
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