ArticleJournal of molecular evolution1993
Evolution of protamine P1 genes in primates.
Article in Journal of molecular evolution, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 62 citations in OpenAlex.
- Protamines and the sperm nuclear basic proteins Pandora's Box of insects.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2024Article
- Ability of a selfish B chromosome to evade genome elimination in the jewel wasp, Nasonia vitripennis.Heredity · 2023Article
- Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions.BMC evolutionary biology · 2020Article
- The c.-190 C>A transversion in promoter region of protamine1 gene as a genetic risk factor for idiopathic oligozoospermia.Molecular biology reports · 2016Article
- Iatrogenic genetic damage of spermatozoa.Advances in experimental medicine and biology · 2014Review
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- H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis.Nucleic acids research · 2010Article
- Methods for incorporating the hypermutability of CpG dinucleotides in detecting natural selection operating at the amino acid sequence level.Molecular biology and evolution · 2009Article
- Comparative analysis of testis protein evolution in rodents.Genetics · 2008Article
- The protamine family of sperm nuclear proteins.Genome biology · 2007Review
- Protamine mRNA as molecular marker for spermatozoa in semen stains.International journal of legal medicine · 2003Article
- A walk though vertebrate and invertebrate protamines.Chromosoma · 2003Review
- Molecular features of the TSPY gene of gibbons and Old World monkeys.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- The evolution of protamine P1 genes in dasyurid marsupials.Journal of molecular evolution · 1995Article
- Sequence analysis and structural features of the largest known protamine isolated from the sperm of the archaeogastropod Monodonta turbinata.Journal of molecular evolution · 1995Article
- Evolution of protamine P1 genes in mammals.Journal of molecular evolution · 1995Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protamine P1 genes have been sequenced by PCR amplification and direct DNA sequencing from 9 primates representing 5 major families, Cebidae (new world monkeys), Cercopithecidae (old world monkeys), Hylobatidae (gibbons), Pongidae (gorilla, orangutan, and chimpanzee), and Hominidae (human). In this recently diverged group of primates these genes are clearly orthologous but very variable, both at the DNA level and in their expressed amino acid sequences. The rate of variation amongst the protamine P1s indicates that they are amongst the most rapidly diverging polypeptides studied. However, some regions are conserved both in primates and generally in other placental mammals. These are the 13 N-terminal residues (including a region of alternating serine and arginine residues (the motif SRSR, res. 10-13) susceptible to Ser phosphorylation), a tract of six Arg residues (res. 24-29) in the center of the molecule, and a six-residue region (RCCRRR, res. 39-44), consisting of a pair of cysteines flanked by arginines. Detailed consideration of nearest-neighbor matrices and trees based on maximum parsimony indicates that P1 genes from humans, gorillas, and chimpanzees are very similar. The amino acid and nucleotide differences between humans and gorillas are fewer than those between humans and chimpanzees. This finding is at variance with data from DNA-DNA hybridization and extensive globin and mitochondrial DNA sequences which place human and chimpanzee as closest relatives in the super family, Hominoidea. This may be related to the fact that protamine P1s are expressed in germ line rather than somatic cells.(ABSTRACT TRUNCATED AT 250 WORDS)
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