Evidence map›Paper›PMID 8308124›Full record

ArticleJournal of clinical microbiology1993

Karyotyping of Cryptococcus neoformans as an epidemiological tool.

J R Perfect, N Ketabchi, G M Cox, C W Ingram, C L Beiser

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 187 citations in OpenAlex.

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  19. Review
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J R PerfectDepartment of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
N Ketabchi
G M Cox
C W Ingram
C L Beiser
Duke Medical Center · USDuke University Hospital · US

Funding

GENTIC &MOLECULAR BIOLOGY OF VIRULENCE IN C. NEOFORMANSR01AI028388 · NIAID · DUKE UNIVERSITY · PI PERFECT, JOHN R. · 1991 to 2004
$1.9M
NIAID NIH HHS 1R01-AI28388-01A2
6 · The paper itself

Abstract

Karyotyping of Cryptococcus neoformans var. neoformans can be used as an epidemiological tool for C. neoformans infections. In this study of over 40 isolates from both clinical and environmental sources, 90% had a unique chromosome banding by pulsed-field electrophoresis. There was no conserved pattern associated with body site of infection, geographical location of the isolate, or human immunodeficiency virus status. Karyotypes of individual isolates remained stable during both in vitro passage and in vivo infections. Karyotype was used to exclude the possibility of nosocomial spread of C. neoformans in one clinical situation and supported relapse in two other cases. Because of its variable sizes between isolates, karyotyping of C. neoformans is a convenient method for molecular identification of different strains.

Indexed as

AdultAIDS-Related Opportunistic InfectionsAnimalsChromosomes, FungalCross InfectionCryptococcosisCryptococcus neoformansDisease Models, AnimalDNA, FungalEnvironmental MicrobiologyEpidemiologic MethodsHumansKaryotypingMaleMeningitis, CryptococcalRabbitsDNA, Fungal

Identifiers

PMID8308124
PMCPMC266409
OpenAlexW2122981636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.