ArticleJournal of clinical microbiology1993
Serological differentiation between cystic and alveolar echinococcosis by use of recombinant larval antigens.
Article in Journal of clinical microbiology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 69 citations in OpenAlex.
- Bacterial Infection of an Alveolar Echinococcus Cyst fromMedicina (Kaunas, Lithuania) · 2023Review
- Article
- Establishing and evaluation of a polymerase chain reaction for the detection of Echinococcus multilocularis in human tissue.PLoS neglected tropical diseases · 2021Article
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (Journal of toxicologic pathology · 2021Review
- Extracellular non-coding RNA signatures of the metacestode stage of Echinococcus multilocularis.PLoS neglected tropical diseases · 2020Article
- Echinococcus vogeli in immigrant from Suriname to the Netherlands.Emerging infectious diseases · 2015Article
- Biochemical and molecular characterization of the tegument protein RT10 from Raillietina tetragona.Parasitology research · 2014Article
- Galα1-4Galβ1-3GalNAc is the dominant epitope of Em2 antigen, the mucin-type glycoprotein from Echinococcus multilocularis.Parasitology research · 2012Article
- Production and immunoanalytical application of 32 monoclonal antibodies against metacestode somatic antigens of Echinococcus multilocularis.Parasitology research · 2010Article
- Molecular characterization of EmABP, an apolipoprotein A-I binding protein secreted by the Echinococcus multilocularis metacestode.Infection and immunity · 2009Article
- Use of two sensitive and specific immunoblot markers, em70 and em90, for diagnosis of alveolar echinococcosis.Journal of clinical microbiology · 2004Article
- Concepts in immunology and diagnosis of hydatid disease.Clinical microbiology reviews · 2003Review
- Alveolar echinococcosis: characterization of diagnostic antigen Em18 and serological evaluation of recombinant Em18.Journal of clinical microbiology · 2002Article
- Serological diagnosis of human cysticercosis by use of recombinant antigens from Taenia solium cysticerci.Clinical and diagnostic laboratory immunology · 1999Article
- Use of enzyme-linked immunosorbent assay and enzyme-linked immunoelectrotransfer blot for the diagnosis and monitoring of neurocysticercosis.Parasitology research · 1995Article
- Identification of a cDNA clone from the larval stage of Echinococcus granulosus with homologies to the E. multilocularis antigen EM10-expressing cDNA clone.Parasitology research · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two recombinant antigens of the larval stages of Echinococcus granulosus and Echinococcus multilocularis, termed EG55 and EM10, respectively, were applied for serodiagnosis and serological differentiation between parasitic infections caused by the metacestode tissue of both tapeworms. Antigen EM10 is synthesized by E. multilocularis larvae. Antigen EG55 represents the recombinant form of the low-molecular-weight subunit of antigen B, which is an Echinococcus genus-specific antigen. Both recombinant antigens were expressed as glutathione S-transferase fusion proteins. A sandwich enzyme-linked immunosorbent assay with monoclonal antibodies against EM10 and EG55 as capture reagents for the recombinant antigens was established and was evaluated with 74 serum samples from patients with histologically confirmed alveolar echinococcosis and 63 serum samples from patients with histologically confirmed cystic echinococcosis. A sensitivity of 93.2% and a specificity of 96.8% were achieved for the serodiagnosis of alveolar echinococcosis. Cystic echinococcosis could be detected with a sensitivity of 89.1% and a specificity of 98.6%.
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