ArticleThe Journal of experimental medicine1977
Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.
Article in The Journal of experimental medicine, 1977. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 179 citations in OpenAlex.
- Eosinophils in mucosal immune responses.Mucosal immunology · 2015Review
- Glycoconjugates in host-helminth interactions.Frontiers in immunology · 2013Review
- T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.The American journal of tropical medicine and hygiene · 2007Article
- Taenia solium metacestode antigens which are protective for pigs induce Th1/Th2 mixed responses in mice.Parasitology research · 2003Article
- Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection.Infection and immunity · 1993Article
- Interleukin-5 is necessary for eosinophilia induced by cyclophosphamide in immunized mice.Immunology · 1993Article
- Human lipoprotein binding to schistosomula of schistosoma mansoni. Displacement by polyanions, parasite antigen masking, and persistence in young larvae.The American journal of pathology · 1989Article
- Human monocyte-derived macrophages are lysed by schistosomula of Schistosoma mansoni and fail to kill the parasite after activation with interferon gamma.The American journal of pathology · 1988Article
- Light and electron microscopic demonstration of phospholipase B activity in the mouse eosinophil.Histochemistry · 1988Article
- Immune surveillance and natural resistance: an evaluation.Cancer immunology, immunotherapy : CII · 1986Review
- Immune responses of CBA/J mice to graded infections with Toxocara canis.Infection and immunity · 1985Article
- Schistosoma japonicum: in vitro killing of schistosomula by mouse neutrophils.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1985Article
- Maturation in vivo of Schistosoma mansoni schistosomula after culture in vitro with granulocytes and antibody.Infection and immunity · 1983Article
- Article
- Evidence for the control of eosinophilia by the major histocompatibility complex in mice.Immunogenetics · 1983Article
- Human eosinophils and parasitic diseases. II. Characterization of two cell fractions isolated at different densities.Clinical and experimental immunology · 1982Article
- Article
- Basis of the specificity of rodent trypanosomes for their natural hosts.Infection and immunity · 1981Article
- Some enzymatic characteristics of eosinophil peroxidase from patients with eosinophilia and from healthy donors.Infection and immunity · 1981Article
- Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro.The Journal of clinical investigation · 1981Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After earlier observations that antibody-dependent, cell-mediated damage to 51Cr-labeled schistosomula can be ablated by pretreatment of a mixed preparation of human peripheral blood leukocytes with an anti-eosinophil serum and complement, we investigated the cytotoxic effects of eosinophil-enriched cell preparations. Preparations containing up to 98.5% eosinophils and devoid of neutrophils were effective in mediating antibody-dependent damage to schistosomula. Preparations enriched in mononuclear cells or in neutrophils, and devoid of eosinophils, were inactive. Eosinophils from some patients with eosinophilia induced by schistosomiasis were less active on a cell-to-cell basis than cells from normal individuals. The possibility that such cells were initially blocked by immune complexes was considered, and it was found that reasonable cytotoxicity by purified eosinophils from patients with eosinophilia could be generated by overnight cultures. A possible requirement for cooperation between eosinophils and other cell types was also studied. Lymphocytes, neutrophils and monocytes failed to enhance eosinophil-mediated cytotoxicity. These results provide further evidence that the eosinophil is the only cell in man responsible for antibody-dependent, complement-independent damage to schistosomula in vitro. Eosinophils from individuals, however, differ in their cytotoxic potential by a mechanism yet to be elucidated. The possible relationship of these findings to immunity in vivo is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.