ArticleThe EMBO journal1994
Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- CCCTC-binding factor recruitment to the early region of the human papillomavirus 18 genome regulates viral oncogene expression.Journal of virology · 2015Article
- Acetylation of conserved lysines in bovine papillomavirus E2 by p300.Journal of virology · 2013Article
- Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots.PloS one · 2013Article
- HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation.Virology journal · 2011Article
- TGF-b2 induction regulates invasiveness of Theileria-transformed leukocytes and disease susceptibility.PLoS pathogens · 2010Article
- Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).Virology · 2008Article
- Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription.Molecular and cellular biology · 2004Article
- Human papillomavirus 16 E6/E7 transcript and E2 gene status in patients with cervical neoplasia.Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology · 2004Article
- Cooperative activation of human papillomavirus type 8 gene expression by the E2 protein and the cellular coactivator p300.Journal of virology · 2002Article
- Transcriptional regulation of the TATA-binding protein by Ras cellular signaling.Molecular and cellular biology · 2000Article
- A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention.Journal of virology · 1997Article
- The ability of C/EBP beta but not C/EBP alpha to synergize with an Sp1 protein is specified by the leucine zipper and activation domain.Molecular and cellular biology · 1997Article
- Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.Journal of virology · 1997Article
- Enhanced transcriptional activation by E2 proteins from the oncogenic human papillomaviruses.Journal of virology · 1996Article
- Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants.Journal of virology · 1996Article
- Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.Molecular and cellular biology · 1996Article
- Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication.Journal of virology · 1996Article
- Heterogeneous nuclear ribonucleoprotein K is a transcription factor.Molecular and cellular biology · 1996Article
- Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.Journal of virology · 1996Article
- E2 represses the late gene promoter of human papillomavirus type 8 at high concentrations by interfering with cellular factors.Journal of virology · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The E2 transactivator protein of bovine papillomavirus 1 (BPV-1) can strongly stimulate complex promoters such as that of the herpes simplex virus thymidine kinase gene but does not efficiently activate minimal promoters that only contain E2 binding sites and a TATA box. Here we show that overexpression of the human, but not yeast, TATA box binding protein (TBP) in transfection experiments overcomes this block and enables E2 to activate a minimal TATA box-containing promoter. This suggests that recruitment of the TFIID complex to such promoters is normally a rate limiting step for transcriptional activation by E2 in vivo. In contrast, minimal promoters that contain an initiator element in addition to a TATA box are efficiently activated by E2 on its own and this activation is only moderately enhanced by TBP overexpression. In such E2-responsive promoters the TATA box or initiator can be functionally replaced by SP1 binding sites. Both the initiator binding protein, TFII-I, and SP1 have been found to interact physically with components of the TFIID complex. Since either TBP overexpression or the presence of an initiator or SP1 binding sites can increase activation by E2, it seems likely that the principal role of the E2 activation domain is to affect a step in the formation of the transcription initiation complex that occurs after TFIID has bound to the promoter. Sequential action of transcription factors, such as TFII-I, SP1 and E2, may be one type of mechanism underlying the widely observed phenomenon of transcriptional synergy.
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