ArticleClinical and experimental immunology1994
Intestinal B cell defects in common variable immunodeficiency.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-Analysis.Journal of clinical immunology · 2024Pooled it
- Diagnostic clues in patients with clinical malabsorption and pathological small intestinal villous atrophy: Immune-mediated type and beyond.World journal of gastroenterology · 2026Review
- IgA and IgM-enriched Immunoglobulins in Primary Immunodeficiencies: a Pilot Study.Journal of clinical immunology · 2025Article
- Gastrointestinal Disease in Common Variable Immunodeficiency Disorder (CVID): Histological Patterns, Diagnostic Clues and Pitfalls for the Pathologist and Gastroenterologist.Journal of clinical medicine · 2025Article
- Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation.Journal of clinical immunology · 2022Article
- What is the role of plasma cell in the lamina propria of terminal ileum in Good's syndrome patient?Open medicine (Warsaw, Poland) · 2021Article
- Infectious Complications Reporting in Common Variable Immunodeficiency: A Systematic Review and Meta-analysis.Oman medical journal · 2020Review
- CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont.Clinical immunology (Orlando, Fla.) · 2018Article
- Ill-defined germinal centers and severely reduced plasma cells are histological hallmarks of lymphadenopathy in patients with common variable immunodeficiency.Journal of clinical immunology · 2014Article
- Common variable immunodeficiency: an update.Arthritis research & therapy · 2012Review
- Pathogenesis and treatment of gastrointestinal disease in antibody deficiency syndromes.The Journal of allergy and clinical immunology · 2009Review
- B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The genetics of hypogammaglobulinemia.Current allergy and asthma reports · 2004Review
- Common variable immunodeficiency (CVID) and MxA-protein expression in blood leucocytes.Clinical and experimental immunology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The humoral immune system of the small intestine of 17 patients with common variable immunodeficiency (CVID) was studied by immunohistology using antibodies specific for IgA1,2, IgM, IgG1-4, the J chain and the secretory component (SC). IgA1,2+, IgG2+ and IgM+ lamina propria B cells were totally lacking in 65% (11/17), 41% (7/17) and 18% (3/17) of CVID patients, respectively. One patient exhibited an isolated IgA1 subclass deficiency. The proportion of plasma cells in conventionally stained histological sections of the same intestinal biopsies showed a close correlation with the numbers of IgA+ and IgM+ cells. Considerable numbers of J chain-synthesizing cells were present in all patients with CVID, indicating the presence of early B cells unable to differentiate into immunoglobulin-producing plasma cells. Most of the patients with intestinal IgA and/or IgM defects strongly expressed the SC in their enterocytes, suggesting an immunoglobulin-independent regulation of the SC. Clinically, only CVID patients with intestinal IgA defects developed intestinal infections with Giardia lamblia, Campylobacter jejuni or Candida albicans. The outcome of in vitro immunoglobulin synthesis assays with peripheral blood lymphocytes did not predict the presence or absence of the respective isotype-producing B cells in the intestinal lamina propria. Thus, immunohistological examinations of intestinal biopsies are required to determine the extent of mucosal immunodeficiency in CVID patients.
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