ArticleProceedings of the National Academy of Sciences of the United States of America1994
Several mRNAs with variable 3' untranslated regions and different stability encode the human PR264/SC35 splicing factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Gene Expression and Alternative Splicing Throughout the Reproductive Cycle of a Viviparous Lizard Reveal Novel Genes for Pregnancy and Convergence With Squamates and Mammals.Molecular ecology · 2026Article
- Splicing factor SRSF2-centric gene regulation.International journal of biological sciences · 2021Review
- Increased Alternative Splicing as a Host Response to Edwardsiella ictaluri Infection in Catfish.Marine biotechnology (New York, N.Y.) · 2018Article
- Regulatory role of the 3' untranslated region (3'UTR) of rat 5' deiodinase (D1). effects on messenger RNA translation and stability.Endocrine · 2005Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
- SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs.The EMBO journal · 2001Article
- Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene.Molecular and cellular biology · 1998Article
- Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene.Nucleic acids research · 1997Article
- The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation.The EMBO journal · 1997Article
- Alternative poly(A) site selection in complex transcription units: means to an end?Nucleic acids research · 1997Review
- Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region.The Biochemical journal · 1996Article
- Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.The EMBO journal · 1995Article
- The beta 1 subunit mRNA of the rat brain Na+ channel is expressed in glial cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have recently established that several mRNAs encode the PR264/SC35 splicing factor and that their expression is related to that of c-Myb in human hematopoietic cells. We now report that the various PR264 mRNAs whose expression is transactivated by c-Myb proteins encode an identical PR264/SC35 polypeptide. These mRNAs differ only in their 3' untranslated sequences and exhibit significantly different half-lives. We also show that there is a direct correlation between the length of the 3' untranslated region and the stability of the mRNA species. Given that 5' and 3' splice site selection mediated by the PR264/SC35 splicing factor is concentration-dependent, we postulate that alternative splicing of the 3' untranslated sequences might represent another key element in regulating the levels of PR264/SC35 expression during hematopoietic differentiation.
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