Evidence map›Paper›PMID 8300236›Full record

ArticleInfection and immunity1994

Evidence for the presence of a high-affinity laminin receptor-like molecule on the surface of Candida albicans yeast cells.

J L López-Ribot, M Casanova, C Monteagudo, P Sepúlveda, J P Martínez

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 86 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J L López-RibotDepartment of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock 79430.
M Casanova
C Monteagudo
P Sepúlveda
J P Martínez
Texas Tech University Health Sciences Center · USTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two polypeptides of 37 and 67 kDa that bind laminin were detected in cell wall extracts of Candida albicans blastoconidia. The 37-kDa species, found only in yeast cell wall extracts, cross-reacted with a rabbit polyclonal antibody (PAb 4160) directed towards the carboxyl-terminal laminin-binding domain present in the human 67-kDa high-affinity laminin receptor (67LR) and its 37-kDa precursor (37LRP), whereas another antibody (PAb 4056), directed against internal domains of 67LR and 37LRP, recognized a 37-kDa species in wall extracts from both blastoconidia and germinated blastoconidia. Indirect immunofluorescence with PAb 4160 showed a patchy binding pattern only on yeast cells that represented about 10% of the entire blastoconidia population.

Indexed as

Amino Acid SequenceAnimalsAntibodies, FungalBinding SitesCandida albicansCell AdhesionCell WallCross ReactionsFluorescent Antibody TechniqueHumansMolecular Sequence DataMolecular WeightOligopeptidesRabbitsReceptors, LamininAntibodies, Fungalarginyl-glycyl-aspartic acidOligopeptidesReceptors, Laminin

Identifiers

PMID8300236
PMCPMC186171
OpenAlexW1962989573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.