ArticleProtein science : a publication of the Protein Society1993
MIF protein are theta-class glutathione S-transferase homologs.
Article in Protein science : a publication of the Protein Society, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Glutathione, polyamine, and lysophosphatidylcholine synthesis pathways are associated with circulating pro-inflammatory cytokines.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Role of macrophage migration inhibitory factor in age-related lung disease.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily.The Biochemical journal · 2001Review
- Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.The Biochemical journal · 1998Article
- Isolation and characterization of glutathione S-transferase isozymes from sorghum.Plant physiology · 1998Article
- Zeta, a novel class of glutathione transferases in a range of species from plants to humans.The Biochemical journal · 1997Article
- Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Evidence for an essential serine residue in the active site of the Theta class glutathione transferases.The Biochemical journal · 1995Article
- Microbes, enzymes and genes involved in dichloromethane utilization.Biodegradation · 1994Review
- Isolation and characterization of octopus hepatopancreatic glutathione S-transferase. Comparison of digestive gland enzyme with lens S-crystallin.Journal of protein chemistry · 1994Article
- Isolation and characterization of the Methylophilus sp. strain DM11 gene encoding dichloromethane dehalogenase/glutathione S-transferase.Journal of bacteriology · 1994Article
- MIF proteins are not glutathione transferase homologs.Protein science : a publication of the Protein Society · 1994Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
MIF proteins are mammalian polypeptides of approximately 13,000 molecular weight. This class includes human macrophage migration inhibitory factor (MIF), a rat liver protein that has glutathione S-transferase (GST) activity (TRANSMIF), and the mouse delayed early response gene 6 (DER6) protein. MIF proteins were previously linked to GSTs by demonstrating transferase activity and observing N-terminal sequence homology with a mu-class GST (Blocki, F.A., Schlievert, P.M., & Wackett, L.P., 1992, Nature 360, 269-270). In this study, MIF proteins are shown to be structurally related to the theta class of GSTs. This is established in three ways. First, unique primary sequence patterns are developed for each of the GST gene classes. The patterns identify the three MIF proteins as theta-like transferase homologs. Second, pattern analysis indicates that GST members of the theta class contain a serine residue in place of the N-terminal tyrosine that is implicated in glutathione deprotonation and activation in GSTs of known structure (Liu, S., et al., 1992, J. Biol. Chem. 267, 4296-4299). The MIF proteins contain a threonine at this position. Third, polyclonal antibodies raised against recombinant human MIF cross-react on Western blots with rat theta GST but not with alpha and mu GSTs. That MIF proteins have glutathione-binding ability may provide a common structural key toward understanding the varied functions of this widely distributed emerging gene family. Because theta is thought to be the most ancient evolutionary GST class, MIF proteins may have diverged early in evolution but retained a glutathione-binding domain.
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