ArticleMolecular biology of the cell1993
How the transition frequencies of microtubule dynamic instability (nucleation, catastrophe, and rescue) regulate microtubule dynamics in interphase and mitosis: analysis using a Monte Carlo computer simulation.
Article in Molecular biology of the cell, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 95 citations in OpenAlex.
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- Computer simulation of merotelic kinetochore-microtubule attachments: corona size is more important than other cell parameters.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Article
- Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction.Biophysical journal · 2019Article
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- Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine.Molecular biology of the cell · 2017Article
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- FLUCTUATING MOTOR FORCES BEND GROWING MICROTUBULES.Cellular and molecular bioengineering · 2013Article
- Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment.Cell cycle (Georgetown, Tex.) · 2013Article
- In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).Journal of computer-aided molecular design · 2012Article
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- Effects of dynein on microtubule mechanics and centrosome positioning.Molecular biology of the cell · 2011Article
- Three-dimensional microtubule behavior in Xenopus egg extracts reveals four dynamic states and state-dependent elastic properties.Biophysical journal · 2008Article
- Survivin modulates microtubule dynamics and nucleation throughout the cell cycle.Molecular biology of the cell · 2006Article
- Computer simulations reveal motor properties generating stable antiparallel microtubule interactions.The Journal of cell biology · 2002Article
- A dynamical model of kinesin-microtubule motility assays.Biophysical journal · 2001Article
- A Landau-Ginzburg Model of the Co-existence of Free Tubulin and Assembled Microtubules in Nucleation and Oscillations Phenomena.Journal of biological physics · 2000Article
- Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Models of assembly and disassembly of individual microtubules: stochastic and averaged equations.Journal of biological physics · 1999Article
- Dissociation of the tubulin-sequestering and microtubule catastrophe-promoting activities of oncoprotein 18/stathmin.Molecular biology of the cell · 1999Article
- Stepwise reconstitution of interphase microtubule dynamics in permeabilized cells and comparison to dynamic mechanisms in intact cells.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microtubules (MTs) in newt mitotic spindles grow faster than MTs in the interphase cytoplasmic microtubule complex (CMTC), yet spindle MTs do not have the long lengths or lifetimes of the CMTC microtubules. Because MTs undergo dynamic instability, it is likely that changes in the durations of growth or shortening are responsible for this anomaly. We have used a Monte Carlo computer simulation to examine how changes in the number of MTs and changes in the catastrophe and rescue frequencies of dynamic instability may be responsible for the cell cycle dependent changes in MT characteristics. We used the computer simulations to model interphase-like or mitotic-like MT populations on the basis of the dynamic instability parameters available from newt lung epithelial cells in vivo. We started with parameters that produced MT populations similar to the interphase newt lung cell CMTC. In the simulation, increasing the number of MTs and either increasing the frequency of catastrophe or decreasing the frequency of rescue reproduced the changes in MT dynamics measured in vivo between interphase and mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.