ArticleBritish journal of cancer1994
K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
Article in British journal of cancer, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Pilot study of mutant ras peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers.Cancer immunology, immunotherapy : CII · 2008Trial
- Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2006Trial
- Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex.Human genomics · 2024Article
- Review
- Genome-Wide Sex and Gender Differences in Cancer.Frontiers in oncology · 2020Review
- Sexual Dimorphism in Colon Cancer.Frontiers in oncology · 2020Review
- Molecular Markers in Sex Differences in Cancer.Toxicological research · 2019Review
- The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.Disease models & mechanisms · 2019Article
- Novel KRAS gene mutations in sporadic colorectal cancer.PloS one · 2014Article
- Screening for differentially expressed genes between left- and right-sided colon carcinoma by microarray analysis.Oncology letters · 2013Article
- A vertically stacked, polymer, microfluidic point mutation analyzer: rapid high accuracy detection of low-abundance K-ras mutations.Analytical biochemistry · 2011Article
- Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.International journal of colorectal disease · 2011Review
- KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways.The Journal of biological chemistry · 2011Article
- Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.World journal of gastroenterology · 2011Article
- Comparative analysis of dideoxy sequencing, the KRAS StripAssay and pyrosequencing for detection of KRAS mutation.World journal of gastroenterology · 2010Article
- Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.BMC medical genetics · 2010Article
- Oncogenetic tree model of somatic mutations and DNA methylation in colon tumors.Genes, chromosomes & cancer · 2009Article
- Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymer microfluidic device.Electrophoresis · 2008Article
- Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.BMC cancer · 2005Article
- Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA from 251 primary tumours obtained from 123 male and 125 female Norwegian patients with colorectal carcinoma was analysed for the presence of K-ras point mutations at codons 12 and 13. Mutations were found in 99 (39%) of the samples. The frequency of K-ras mutations was significantly related to age and sex of the patients, and to the location of the tumours (overall: P = 0.008). K-ras mutations were much less frequent in colonic tumours from male than female patients at younger ages (< 40 years, odds ratio < 0.014). The low frequency might indicate that a different, ras-independent, pathway to neoplasia is dominating in the colon of younger males. In contrast, older men had more mutations than older women (e.g. 90 years, odds ratio = 5.8). An inverse but less pronounced relationship was seen for rectal tumours. The type of mutation was found to be associated to sex of patient and location of tumour. G-->C transversions accounted for 35% of the mutations in rectal tumours from females, in contrast to only 2.5% in the rest of the material (P = 0.0005). This may indicate that there are specific carcinogens acting in this location.
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