ArticleThe Journal of experimental medicine1994
Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.
Article in The Journal of experimental medicine, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
- Insights into the host response to 'dormant' Mycobacterium tuberculosis utilizing 'Vitamin C-induced dormant Mtb' THP-1 cell infection model.BMC genomics · 2026Article
- Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?Applied microbiology and biotechnology · 2019Review
- Mycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infection.PLoS pathogens · 2017Article
- Murine norovirus replication induces G0/G1 cell cycle arrest in asynchronously growing cells.Journal of virology · 2015Article
- Cell cycle regulation during viral infection.Methods in molecular biology (Clifton, N.J.) · 2014Review
- Kaposi's sarcoma-associated herpesvirus transactivator Rta induces cell cycle arrest in G0/G1 phase by stabilizing and promoting nuclear localization of p27kip.Journal of virology · 2013Article
- Virus manipulation of cell cycle.Protoplasma · 2012Review
- Human herpesvirus 6 suppresses T cell proliferation through induction of cell cycle arrest in infected cells in the G2/M phase.Journal of virology · 2011Article
- Quiescence: a mechanism for escaping the effects of drug on cell populations.Journal of the Royal Society, Interface · 2011Article
- Influenza A virus replication induces cell cycle arrest in G0/G1 phase.Journal of virology · 2010Article
- SARS coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin D3/pRb pathway.Virology · 2006Article
- Murine coronavirus replication induces cell cycle arrest in G0/G1 phase.Journal of virology · 2004Article
- The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation.Oncogene · 2002Article
- Induction and inhibition of apoptosis by pseudorabies virus in the trigeminal ganglion during acute infection of swine.Journal of virology · 2001Article
- Cancer dormancy and cell signaling: induction of p21(waf1) initiated by membrane IgM engagement increases survival of B lymphoma cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- S-phase-dependent cell cycle disturbances caused by Aleutian mink disease parvovirus.Journal of virology · 1997Article
- Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions.British journal of cancer · 1997Article
- The role of vaccines in the control of STDs: HPV vaccines.Genitourinary medicine · 1996Review
- Targeting of peripheral blood T lymphocytes.Springer seminars in immunopathology · 1996Review
- Involvement of CD80 in the generation of CD4+ cytotoxic T cells.Immunologic research · 1996Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cytotoxic T lymphocytes (CTL) kill cells by perturbing the target's plasma membrane and by inducing the disintegration of the target cell's DNA into oligonucleosomal fragments, a process characteristic of apoptosis. We show that the DNA fragmentation event is distinct from the membrane lysis event and is dependent on the state of target cell activation or commitment into the mitotic cycle. Quiescent cells were refractory to DNA fragmentation, but not to membrane lysis. Log phase growth, transformation with c-myc, or infection of quiescent G0 targets with herpes simplex virus-1, which induces a competent state for DNA synthesis, all enhanced target cell susceptibility to CTL-induced DNA fragmentation without altering the membrane lysis. These results suggest that G0 cells are resistant to CTL-induced apoptosis, but that entry into G1 or a G1-like state by growth factors, cellular transformation, or DNA virus infection renders them competent to enter the apoptotic pathway(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.