ArticleThe Journal of cell biology1994
Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 113 citations in OpenAlex.
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration.Biophysical journal · 2011Article
- Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.The Journal of biological chemistry · 2008Article
- Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cysteine-rich protein 1 (CRP1) regulates actin filament bundling.BMC cell biology · 2005Article
- Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione.Nucleic acids research · 2005Article
- Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation.Journal of virology · 2001Article
- Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity.Molecular and cellular biology · 2001Article
- A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila.EMBO reports · 2001Article
- Fine mapping of the alpha-actinin binding site within cysteine-rich protein.The Biochemical journal · 2000Article
- Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis.Molecular biology of the cell · 1999Article
- Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.Molecular and cellular biology · 1999Article
- The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells.Molecular and cellular biology · 1999Article
- A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.The Journal of cell biology · 1999Article
- LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function.The Biochemical journal · 1998Article
- DdLIM is a cytoskeleton-associated protein involved in the protrusion of lamellipodia in Dictyostelium.Molecular biology of the cell · 1998Article
- Linkage mapping of Csrp to proximal mouse chromosome 3.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin.The Journal of cell biology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LIM domains are present in a number of proteins including transcription factors, a proto-oncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., 1993). Previously, we reported the identification of a 23-kD protein that interacts with zyxin in vitro (Sadler et al., 1992). In this report, we describe the purification and characterization of this 23-kD zyxin-binding protein from avian smooth muscle. Isolation of a cDNA encoding the 23-kD protein has revealed that it consists of 192 amino acids and exhibits two copies of the LIM motif. The 23-kD protein is 91% identical to the human cysteine-rich protein (hCRP); therefore we refer to it as the chicken cysteine-rich protein (cCRP). Examination of a number of chick embryonic tissues by Western immunoblot analysis reveals that cCRP exhibits tissue-specific expression. cCRP is most prominent in tissues that are enriched in smooth muscle cells, such as gizzard, stomach, and intestine. In primary cell cultures derived from embryonic gizzard, differentiated smooth muscle cells exhibit the most striking staining with anti-cCRP antibodies. We have performed quantitative Western immunoblot analysis of cCRP, zyxin, and alpha-actinin levels during embryogenesis. By this approach, we have demonstrated that the expression of cCRP is developmentally regulated.
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