ArticleGenetics1993
Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth.
Article in Genetics, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Cell wall staining with Trypan blue enables quantitative analysis of morphological changes in yeast cells.Frontiers in microbiology · 2015Article
- The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae.Aging cell · 2013Article
- Role of actin-bundling protein Sac6 in growth of Cryptococcus neoformans at low oxygen concentration.Eukaryotic cell · 2012Article
- Dynactin function in mitotic spindle positioning.Traffic (Copenhagen, Denmark) · 2008Article
- Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.Molecular biology of the cell · 2007Article
- Deficiencies in the endoplasmic reticulum (ER)-membrane protein Gab1p perturb transfer of glycosylphosphatidylinositol to proteins and cause perinuclear ER-associated actin bar formation.Molecular biology of the cell · 2004Article
- Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance.The Journal of cell biology · 2004Article
- Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.Molecular biology of the cell · 2001Article
- Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Molecular biology of the cell · 2000Article
- Role of polo kinase and Mid1p in determining the site of cell division in fission yeast.The Journal of cell biology · 1998Article
- A morphogenesis checkpoint monitors the actin cytoskeleton in yeast.The Journal of cell biology · 1998Article
- Depolarization of the actin cytoskeleton is a specific phenotype in Saccharomyces cerevisiae.Journal of cell science · 1998Article
- Identification of functional connections between calmodulin and the yeast actin cytoskeleton.Genetics · 1998Article
- Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1.Molecular biology of the cell · 1998Article
- Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis.Genetics · 1997Article
- Article
- BRO1, a novel gene that interacts with components of the Pkc1p-mitogen-activated protein kinase pathway in Saccharomyces cerevisiae.Molecular and cellular biology · 1996Article
- Mutational analysis of capping protein function in Saccharomyces cerevisiae.Molecular biology of the cell · 1996Article
- BED1, a gene encoding a galactosyltransferase homologue, is required for polarized growth and efficient bud emergence in Saccharomyces cerevisiae.The Journal of cell biology · 1996Article
- Actin filaments in yeast are unstable in the absence of capping protein or fimbrin.The Journal of cell biology · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mutations conferring synthetic lethality in combination with null mutations in CAP2, the gene encoding the beta subunit of capping protein of Saccharomyces cerevisiae, were obtained in a colony color assay. Monogenic inheritance was found for four mutations, which were attributed to three genetic loci. One mutation, sac6-69, is in the gene encoding fimbrin, another actin-binding protein, which was expected because null mutations in SAC6 and CAP2 are known to be synthetic-lethal. The other two loci were designated slc for synthetic lethality with cap2. These loci include the mutations slc1-66, slc1-87 and slc2-107. The slc mutations are semi-dominant, as shown by incomplete complementation in slc/SLC cap2/cap2 heterozygotes. The slc mutations and sac6-69 interact with each other, as shown by enhanced phenotypes in diheterozygotes. Moreover, the haploid slc2-107 sac6-69 double mutant is inviable. In a CAP2 background, the slc mutations lead to temperature and osmotic sensitivity. They alter the distribution of the actin cytoskeleton, including deficits in the presence of actin cables and the polarization of cortical actin patches. The slc mutations also lead to a pseudomycelial growth pattern. Together these results suggest that slc1 and slc2 encode components of the actin cytoskeleton in yeast and that the actin cytoskeleton can regulate the patterns of growth.
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