ArticlePlant molecular biology1993
Molecular cloning and evolutionary analysis of the calcium-modulated contractile protein, centrin, in green algae and land plants.
Article in Plant molecular biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
- Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition.International journal of molecular sciences · 2021Review
- Review
- Centrin/Cdc31 is a novel regulator of protein degradation.Molecular and cellular biology · 2008Article
- Centrin scaffold in Chlamydomonas reinhardtii revealed by immunoelectron microscopy.Eukaryotic cell · 2005Article
- Sfi1p has conserved centrin-binding sites and an essential function in budding yeast spindle pole body duplication.The Journal of cell biology · 2003Article
- Article
- A rapid induction by elicitors of the mRNA encoding CCD-1, a 14kDa Ca2+ -binding protein in wheat cultured cells.Plant molecular biology · 2000Article
- Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Phylogenetic relationships within Hevea brasiliensis as deduced from a polymorphic mitochondrial DNA region.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 1995Article
- The light chain p28 associates with a subset of inner dynein arm heavy chains in Chlamydomonas axonemes.Molecular biology of the cell · 1995Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Centrin (= caltractin) is a ubiquitous, cytoskeletal protein which is a member of the EF-hand superfamily of calcium-binding proteins. A centrin-coding cDNA was isolated and characterized from the prasinophyte green alga Scherffelia dubia. Centrin PCR amplification primers were used to isolate partial, homologous cDNA sequences from the green algae Tetraselmis striata and Spermatozopsis similis. Annealing analyses suggested that centrin is a single-copy-coding region in T. striata and S. similis and other green algae studied. Centrin-coding regions from S. dubia, S. similis and T. striata encode four colinear EF-hand domains which putatively bind calcium. Phylogenetic analyses, including homologous sequences from Chlamydomonas reinhardtii and the land plant Atriplex nummularia, demonstrate that the domains of centrins are congruent and arose from the two-fold duplication of an ancestral EF hand with Domains 1+3 and Domains 2+4 clustering. The domains of centrins are also congruent with those of calmodulins demonstrating that, like calmodulin, centrin is an ancient protein which arose within the ancestor of all eukaryotes via gene duplication. Phylogenetic relationships inferred from centrin-coding region comparisons mirror results of small subunit ribosomal RNA sequence analyses suggesting that centrin-coding regions are useful evolutionary markers within the green algae.
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