ArticleJournal of molecular neuroscience : MN1993
Learning and sexual deficiencies in transgenic mice carrying a chimeric vasoactive intestinal peptide gene.
Article in Journal of molecular neuroscience : MN, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- (Neuro) Peptides, Physical Activity, and Cognition.Journal of clinical medicine · 2020Review
- The neuropeptide vasoactive intestinal peptide: direct effects on immune cells and involvement in inflammatory and autoimmune diseases.Acta physiologica (Oxford, England) · 2015Review
- Serum levels of vasoactive intestinal peptide as a prognostic marker in early arthritis.PloS one · 2014Article
- Spatiotemporal distribution of vasoactive intestinal polypeptide receptor 2 in mouse suprachiasmatic nucleus.The Journal of comparative neurology · 2012Article
- Lateralized hippocampal effects of vasoactive intestinal peptide on learning and memory in rats in a model of depression.Psychopharmacology · 2012Article
- VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice.PloS one · 2012Article
- Neuropeptide GPCRs in neuroendocrinology: the case of activity-dependent neuroprotective protein (ADNP).Frontiers in endocrinology · 2012Article
- VIP-PACAP 2010: my own perspective on modulation of cognitive and emotional behavior.Journal of molecular neuroscience : MN · 2010Article
- The involvement of PACAP/VIP system in the synaptic transmission in the hippocampus.Journal of molecular neuroscience : MN · 2010Article
- VIP, from gene to behavior and back: summarizing my 25 years of research.Journal of molecular neuroscience : MN · 2008Article
- Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2008Article
- Select cognitive deficits in vasoactive intestinal peptide deficient mice.BMC neuroscience · 2008Article
- Vasoactive intestinal peptide (VIP) regulates activity-dependent neuroprotective protein (ADNP) expression in vivo.Journal of molecular neuroscience : MN · 2007Article
- Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistry.Journal of molecular neuroscience : MN · 2007Article
- Neonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation.Journal of molecular neuroscience : MN · 2006Article
- Review
- A glia-derived signal regulating neuronal differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Protection against developmental deficiencies by a lipophilic VIP analogue.Neurochemical research · 1998Article
- Identification of VIP/PACAP receptors on rat astrocytes using antisense oligodeoxynucleotides.Journal of molecular neuroscience : MN · 1997Article
- Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms responsible for behavior are largely unknown. A state of the art model, paving the path from genes to behavior, is offered by transgenic animals. Candidate molecules are classic neuropeptides, such as vasoactive intestinal peptide (VIP). Transgenic mice harboring a chimeric VIP gene driven by the polyoma promoter were produced. Behavioral studies revealed learning impairment and prolonged retardation in memory acquisition in the genetically altered animals. Furthermore, reduced performance was observed when the male transgenic mice were tested for sexual activity in the presence of receptive females. Surprisingly, radioimmunoassays showed an approx 20% decrease in the VIP content of the transgenic mice brains. To directly assess genetically reduced VIP content as a cause for learning impairment, transgenic mice carrying diphtheria toxin-encoding sequences driven by the rat VIP promoter were created. These animals had reduced brain VIP and exhibited deficiencies in learning abilities, strongly supporting an important neurobiological function for VIP in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.