ArticleThe American journal of pathology1994
Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 113 citations in OpenAlex.
- Article
- Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress.International journal of molecular sciences · 2019Article
- Effect of Thrombin-Induced MCP-1 and MMP-3 Production Via PAR1 Expression in Murine Intervertebral Discs.Scientific reports · 2018Article
- Article
- Role of tissue factor in the maternal immunological attack of the embryo in the antiphospholipid syndrome.Clinical reviews in allergy & immunology · 2010Review
- Local protease signaling contributes to neural tube closure in the mouse embryo.Developmental cell · 2010Article
- Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro.Reproductive biology and endocrinology : RB&E · 2005Article
- Distinct PAR/IQGAP expression patterns during murine development: implications for thrombin-associated cytoskeletal reorganization.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain.The Journal of clinical investigation · 2000Article
- How the protease thrombin talks to cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Review
- Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Prothrombin deficiency results in embryonic and neonatal lethality in mice.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Differential transcriptional regulation of the human thrombin receptor gene by the Sp family of transcription factors in human endothelial cells.The Biochemical journal · 1998Article
- Low levels of tissue factor are compatible with development and hemostasis in mice.The Journal of clinical investigation · 1998Article
- Mice lacking the thrombin receptor, PAR1, have normal skin wound healing.The American journal of pathology · 1997Article
- Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.The Journal of clinical investigation · 1997Article
- Tissue factor expression during human and mouse development.The American journal of pathology · 1996Article
- The serine protease granzyme A does not induce platelet aggregation but inhibits responses triggered by thrombin.The Biochemical journal · 1996Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The protease thrombin is a potent agonist for platelet aggregation, mesenchymal cell proliferation, and endothelial production of growth factors and adhesion molecules. Thrombin also modulates neurite outgrowth in neuronal cultures. These apparently disparate responses to thrombin appear to be largely mediated by the recently cloned thrombin receptor. In the adult, thrombin is generated from its zymogen prothrombin at sites of vascular injury when circulating coagulation factors meet extravascular tissue factor. In this context thrombin's varied actions may mediate responses to wounding. Whether thrombin's actions on cells may also play a role in development is unknown. We examined the expression of thrombin receptor, prothrombin, and tissue factor by in situ hybridization in mouse development. Thrombin receptor mRNA was expressed widely in mesenchymal cell populations during early organogenesis (E9.5) and was particularly abundant in developing heart and blood vessels. Robust receptor expression was also noted in the germinal epithelium of the hindbrain. Thrombin receptor expression became more restricted with time and by the fetal growth stage (E16.5) was most readily detected in certain neurons, endocardial and endothelial cells, and within lung and liver. In contrast to the thrombin receptor, prothrombin mRNA was limited to the embryonic liver and was not detected until E12.5, well after the onset of receptor expression. mRNA for tissue factor, one important trigger for thrombin generation in the adult, was detected in embryonic epithelia from E9.5-12.5. In several instances, tissue factor-expressing epithelia were surrounded by thrombin receptor-expressing mesenchyme. These data suggest a possible role for the thrombin receptor in development. The finding of robust thrombin receptor expression before prothrombin mRNA was detected raises the question of whether other proteases or peptide ligands can activate the thrombin receptor.
Indexed as
Identifiers
8291612PMC1887128W184434952What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.