ArticleThe American journal of pathology1994
Deletion mapping of chromosome 8p in colorectal carcinoma and dysplasia arising in ulcerative colitis, prostatic carcinoma, and malignant fibrous histiocytomas.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.Molecular cancer research : MCR · 2008Article
- High-resolution physical map and transcript identification of a prostate cancer deletion interval on 8p22.Genome research · 2000Article
- Article
- Chromosome 8p deletions are associated with invasive tumor growth in urinary bladder cancer.The American journal of pathology · 1997Article
- Analysis of genetic changes underlying local recurrence of prostate carcinoma during androgen deprivation therapy.The American journal of pathology · 1995Article
- Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Prostate cancer progression. Implications of histopathology.The American journal of pathology · 1994Review
- Keratinocyte growth factor induces pancreatic ductal epithelial proliferation.The American journal of pathology · 1994Article
- HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization.The American journal of pathology · 1994Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Short tandem repeat polymorphism markers on the short arm of chromosome 8 were used to search for loss of heterozygosity (LOH) in colorectal carcinoma and dysplasia complicating ulcerative colitis, in prostatic carcinoma, and in malignant fibrous histiocytoma (MFH). Fifty percent of prostatic carcinomas (13/26), 44% of carcinomas or dysplasias arising in ulcerative colitis (7/16), and 30% (4/12) of MFH cases showed LOH for markers on 8p. Detailed mapping demonstrated variability in the size of the chromosomal region showing LOH; however, the data suggest a common 30-centimorgan region of LOH on chromosome 8p between the LPL locus and pter in colorectal and prostatic cancers. In addition, LOH was observed on 8p in both high-grade and low-grade dysplasia in ulcerative colitis, indicating that LOH on 8p may occur at an early stage of neoplastic development in this disorder. In contrast, MFH cases exhibited LOH for marker D8S87, which has been identified as being near the putative Werner's syndrome locus. These results suggest that a tumor suppressor gene, located on the distal portion of chromosome 8p, exists in common for prostatic and colorectal carcinomas, and a second tumor suppressor gene may exist linked to the Werner's syndrome locus.
Indexed as
Identifiers
8291601PMC1887129W272049967What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.