ArticleVirchows Archiv. A, Pathological anatomy and histopathology1993
Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 43 citations in OpenAlex.
- Ascitic Fluid Cytology Provides Diagnostic Clues in a Case of Gastric Metastasis from Invasive Lobular Carcinoma of the Breast.Surgical case reports · 2026Article
- Clinical and biological implications of the tumor microenvironment.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome.Breast cancer research : BCR · 2004Article
- Biological features of premalignant disease in the human breast.Journal of mammary gland biology and neoplasia · 2000Review
- p53 gene mutations and expression of p53 and mdm2 proteins in invasive breast carcinoma. A comparative analysis with clinico-pathological factors.Journal of cancer research and clinical oncology · 1997Article
- Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.Journal of clinical pathology · 1996Article
- Prognostic factors in primary breast carcinoma.Journal of clinical pathology · 1995Article
- Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators.British journal of cancer · 1995Article
- Loss of heterozygosity in lobular carcinoma in situ of the breast.Clinical molecular pathology · 1995Article
- Immunohistochemical Expression of Vimentin in Invasive Breast Carcinoma and Its Correlation with Clinicopathological Parameters.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- A component of lobular carcinoma in clinically lymph node-negative patients predicts for an increased likelihood of upstaging to pathologic stage III breast cancer.Advances in radiation oncologyArticle
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5 authors at 3 institutions in 2 countries.
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Abstract
Vimentin, p53 protein and cathepsin D positivity were assessed by immunohistochemistry, and oestrogen receptor (ER) by an enzyme immunoassay, in invasive lobular carcinomas (LC) of the breast. While vimentin was positive in only 5% (3/57) and p53 protein was positive only in 3% (2/63), cathepsin D was expressed in 86% (48/56) and ER in 78% (25/32). Classical LC were negative for p53 protein and all except one were cathepsin D positive. These results are in contrast to invasive ductal breast carcinomas (DC), where the reported average incidence of vimentin and p53 protein is much higher (19% and 33% respectively) and that of cathepsin D and ER lower (63% and 67% respectively). Thus lack of expression of vimentin and lack of p53 positivity together with high incidence of expression of cathepsin D and ER are more often associated with lobular than with ductal differentiation of invasive breast cancer. The results show that LC, distinguished morphologically, can further be defined by its immunohistochemical profile. This in turn may point to underlying biological differences between LC and DC.
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