ArticleVirchows Archiv. A, Pathological anatomy and histopathology1993
Expression of progesterone receptors in solid-cystic tumour of the pancreas: a clinicopathological and immunohistochemical study of ten cases.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 94 citations in OpenAlex.
- Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy.Discover oncology · 2025Review
- Article
- Delayed Presentation of Metastatic Solid Pseudopapillary Epithelial Neoplasm in a Pregnant Woman: A Case Report.Cureus · 2025Article
- Solid pseudopapillary tumor of the pancreas mistaken for gastrointestinal stromal tumor: A case report.SAGE open medical case reports · 2024Article
- PANCREATIC SOLID-PSEUDOPAPILLARY NEOPLASM IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Article
- Solid pseudopapillary neoplasms of the pancreas: Case series with a review of the literature.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Review
- Huge solid pseudopapillary tumor of the pancreas 'Frantz tumor': a case report.Journal of gastrointestinal oncology · 2020Article
- CD200 expression is a feature of solid pseudopapillary neoplasms of the pancreas.Virchows Archiv : an international journal of pathology · 2019Article
- Solid pseudopaillary neoplasm of the pancreas: analysis of clinicopathological and immunohistochemical features in 10 cases.International journal of clinical and experimental pathology · 2018Article
- Pancreatic mucinous cystoadenomas and cystoadenocarcinomas: differential diagnosis by means of MRI.The British journal of radiology · 2016Article
- Cystic lesions of the pancreas: Improved understanding, diagnostics and refined outcomes.South Asian journal of cancer · 2013Article
- Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm.World journal of gastroenterology · 2013Review
- Pseudopapillary tumor in pediatric age: clinical and surgical management.Pediatric surgery international · 2011Article
- Mucinous cystadenocarcinoma of the pancreas diagnosed in postpartum.Langenbeck's archives of surgery · 2007Article
- Solid pseudopapillary neoplasm of the pancreas: a single institution experience of 14 cases.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2006Article
- Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review.World journal of gastroenterology · 2005Review
- Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis.British journal of cancer · 2001Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A role for sex hormones in the pathogenesis of solid-cystic tumour (SCT) of the pancreas is suggested by its predilection for young fertile women. Controversial data have been provided for the presence of progesterone receptors (PR) and/or oestrogen receptors (ER) in SCT. We report the immunohistochemical detection of PR in ten cases of SCT. Eight were from young women. The remaining two were from a post-menopausal woman and a young boy. All cases showed PR immunoreactivity in the large majority of neoplastic cells, whereas none exhibited ER positivity. In one tumour two types of cell populations were noted, the more anaplastic invasive-type being PR negative, whereas the more typical was PR positive. PR immunoreactivity in the absence of ER may simply reflect a lower sensitivity of ER antibody failing to reveal the biochemically detectable ER, or that the PR in cells of SCT are constitutively synthesized in an oestrogen-independent way, as in T47D breast carcinoma cell line, meningioma cells and some gastric cancer cells. Our findings support the hypothesis of a possible pathogenetic role of progesterone in SCT, independent of the patient's sex and age.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.