ArticleProceedings of the National Academy of Sciences of the United States of America1994
Weak male-driven molecular evolution in rodents.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 122 citations in OpenAlex.
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- Germline mutation rate is elevated in young and old parents inEvolution letters · 2023Article
- X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease.Experimental neurology · 2023Review
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- Overlooked roles of DNA damage and maternal age in generating human germline mutations.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Male Mutation Bias Is the Main Force Shaping Chromosomal Substitution Rates in Monotreme Mammals.Genome biology and evolution · 2017Article
- Interpreting the Dependence of Mutation Rates on Age and Time.PLoS biology · 2016Article
- The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains.Biology of sex differences · 2016Article
- GC-biased gene conversion in yeast is specifically associated with crossovers: molecular mechanisms and evolutionary significance.Molecular biology and evolution · 2013Article
- Estimating divergence times in large molecular phylogenies.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Genome analyses substantiate male mutation bias in many species.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- Doubts about complex speciation between humans and chimpanzees.Trends in ecology & evolution · 2009Article
- Evidence that replication-associated mutation alone does not explain between-chromosome differences in substitution rates.Genome biology and evolution · 2009Article
- Characterization of the bovine pseudoautosomal boundary: Documenting the evolutionary history of mammalian sex chromosomes.Genome research · 2008Article
- Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes.Molecular ecology · 2008Article
- Sperm competition can drive a male-biased mutation rate.Journal of theoretical biology · 2007Article
- Characteristics, causes and evolutionary consequences of male-biased mutation.Proceedings. Biological sciences · 2007Review
- Mammalian male mutation bias: impacts of generation time and regional variation in substitution rates.Journal of molecular evolution · 2006Article
- Substitution rate heterogeneity and the male mutation bias.Journal of molecular evolution · 2006Article
- The scale of mutational variation in the murid genome.Genome research · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In humans and rodents the male-to-female ratio of mutation rate (alpha m) has been suggested to be extremely large, so that the process of nucleotide substitution is almost completely male-driven. However, our sequence data from the last intron of the X chromosome-linked (Zfx) and Y chromosome-linked (Zfy) zinc finger protein genes suggest that alpha m is only approximately 2 in rodents with a 95% confidence interval from 1 to 3. Moreover, from published data on oogenesis and spermatogenesis we estimate the male-to-female ratio of the number of germ cell divisions per generation to be approximately 2 in rodents, confirming our estimate of alpha m and suggesting that errors in DNA replication are the primary source of mutation. As the estimated alpha m for rodents is only one-third of our previous estimate of approximately 6 for higher primates, there appear to be generation-time effects--i.e., alpha m decreases with decreasing generation time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.