ArticleProceedings of the National Academy of Sciences of the United States of America1994
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 128 citations in OpenAlex.
- Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells.Endocrinology · 2015Article
- Decorin differentially modulates the activity of insulin receptor isoform A ligands.Matrix biology : journal of the International Society for Matrix Biology · 2014Article
- The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation.Molecular and cellular biology · 2013Article
- Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.The Journal of biological chemistry · 2012Article
- Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A.The Journal of biological chemistry · 2012Article
- Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.The Journal of biological chemistry · 2011Article
- An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol.The Journal of endocrinology · 2010Article
- Transgenic overexpression of insulin receptor substrate 1 in hepatocytes enhances hepatocellular proliferation in young mice only.Hepatology research : the official journal of the Japan Society of Hepatology · 2008Article
- Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma.Cancer science · 2008Article
- Expression of insulin receptor substrate 1 in primary breast cancer and lymph node metastases.Journal of clinical pathology · 2005Article
- The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation.Molecular and cellular biology · 2002Article
- Augmentation effect of postprandial hyperinsulinaemia on growth of human hepatocellular carcinoma.Gut · 2002Article
- Article
- Role of binding proteins to IRS-1 in insulin signalling.Molecular and cellular biochemistry · 1998Review
- A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.Molecular and cellular biology · 1998Article
- Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes.Molecular and cellular biology · 1997Article
- Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.The Journal of clinical investigation · 1997Article
- Insulin-like growth factor I receptor signaling in transformation by src oncogenes.Molecular and cellular biology · 1997Article
- Insulin-like growth factor II stimulates cell proliferation through the insulin receptor.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Insulin treatment of mammalian cells immediately stimulates the tyrosine phosphorylation of a cellular protein of 185 kDa referred to as pp185 or IRS-1 (insulin receptor substrate 1). The potential role of the IRS-1 protein in insulin signaling has been examined by microinjecting affinity-purified antibodies into living cells. Stably transfected Rat-1 fibroblasts, which overexpress the human insulin receptor, were microinjected and subsequently stimulated with insulin or other growth factors. Progression through the cell cycle was monitored by using a single-cell assay, which employs bromodeoxyuridine labeling of DNA and analysis with immunofluorescence microscopy. Microinjection of anti-IRS-1 antibody completely inhibited incorporation of bromodeoxyuridine into the nuclei of cells stimulated with insulin or insulin-like growth factor I but did not affect cells stimulated with serum or a variety of purified growth factors. These studies indicate that IRS-1 is a critical component of the insulin and insulin-like growth factor I signaling pathways, which lead to DNA synthesis and cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.