ArticlePostgraduate medical journal1993
Prognostic factors in Wegener's granulomatosis.
Article in Postgraduate medical journal, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 26 citations in OpenAlex.
- Granulomatosis with polyangiitis manifesting as fever of unknown origin.BMJ case reports · 2021Article
- Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis.Journal of the American Society of Nephrology : JASN · 2017Article
- Simple, readily available clinical indices predict early and late mortality among patients with ANCA-associated vasculitis.BMC nephrology · 2017Article
- Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts.Arthritis and rheumatism · 2008Article
- ANCA-associated vasculitis: diagnosis and treatment in the elderly.Postgraduate medical journal · 1996Review
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Authors and funding
4 authors.
Funding
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Abstract
We analysed data from 64 patients with Wegener's granulomatosis to determine predictor variables of outcome. The mean period of observation after the diagnosis had been established was 3.2 (range 0.1-11.2) years. At the time of diagnosis, 15 (23%) patients had only local symptoms. The disease was generalized to multiple organs in 49 (77%) patients. Renal biopsies were obtained in 33 patients; 13 (39%) had extracapillary glomerulonephritis, which was the most common renal lesion. All but three patients received immunosuppressive therapy. At time of follow-up, 17 (27%) patients were in complete, and 26 (40%) in partial remission. We employed a Kaplan Meier analysis to identify predictor variables of outcome. Renal involvement, initial creatinine concentration, serum albumin or total protein concentration, leukocyte count and erythrocyturia proved to be predictor variables. These variables may be of value in guiding the intensity of treatment in patients with Wegener's granulomatosis.
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