ArticleMolecular and cellular biology1994
A unique palindromic element mediates gamma interferon induction of mig gene expression.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 90 citations in OpenAlex.
- A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment.Cellular and molecular life sciences : CMLS · 2023Review
- Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.Frontiers in immunology · 2017Review
- Regulation of chemokine expression in the tumor microenvironment.Critical reviews in immunology · 2014Review
- Review
- CXCR3 ligands: redundant, collaborative and antagonistic functions.Immunology and cell biology · 2011Review
- The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The benzoxathiolone LYR-71 down-regulates interferon-gamma-inducible pro-inflammatory genes by uncoupling tyrosine phosphorylation of STAT-1 in macrophages.British journal of pharmacology · 2009Article
- Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.Journal of virology · 2008Article
- CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection.Journal of virology · 2007Article
- Stat1 and SUMO modification.Blood · 2006Article
- Proximal genomic localization of STAT1 binding and regulated transcriptional activity.BMC genomics · 2006Article
- In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy.Oncogene · 2005Article
- Constitutive nuclear factor kappaB activity is required to elicit interferon-gamma-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines.The Biochemical journal · 2003Article
- T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines.Cancer gene therapy · 2003Article
- Article
- Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2000Article
- Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes.Gene therapy · 2000Article
- Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense.The Journal of clinical investigation · 2000Article
- Variegation of retroviral vector gene expression in myeloid cells.Gene therapy · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To define the molecular mechanisms involved in the action of gamma interferon (IFN-gamma), we have analyzed the transcriptional regulation of the mig (monokine induced by gamma interferon) gene, a member of the platelet factor 4-interleukin-8 cytokine family that is expressed in murine macrophages specifically in response to IFN-gamma. Analysis of mig/CAT chimeric constructs transiently transfected into the RAW 264.7 mouse monocytic cell line revealed a unique IFN-gamma-responsive element (gamma RE-1). The sequence of this cis regulatory element defined by deletion analysis contains an imperfect inverted repeat extending 27 bp. Examination of mig/CAT constructs with mutations in gamma RE-1 revealed that the palindromic positions in the element were essential for activity. Consistent with its function as an enhancer, a single copy of gamma RE-1 conferred IFN-gamma inducibility to a heterologous (herpes simplex virus thymidine kinase) promoter. Exonuclease III protection assays demonstrated symmetrical protection of a mig promoter fragment centered about the gamma RE-1 palindromic sequence. Using the gel electrophoretic mobility shift assay, we identified a factor (gamma RF-1) present in nuclear extracts prepared from IFN-gamma-stimulated RAW 264.7 cells which binds to gamma RE-1. The activation of gamma RF-1 occurred rapidly (within 1 min) in response to IFN-gamma and was independent of protein synthesis. Similar to the expression of mig mRNA, the formation of gamma RF-1 was selectively induced by IFN-gamma and not IFN-alpha. The regulation of gene expression through gamma RF-1 and gamma RE-1 may explain the preferential activation of a subset of interferon-inducible genes by IFN-gamma.
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Registered trials
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