ArticleMolecular and cellular biology1994
Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- Isoform-Directed Control of c-Myc Functions: Understanding the Balance from Proliferation to Growth Arrest.International journal of molecular sciences · 2023Review
- MYC protein interactors in gene transcription and cancer.Nature reviews. Cancer · 2021Review
- Multiple direct interactions of TBP with the MYC oncoprotein.Nature structural & molecular biology · 2019Article
- TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Stimulation of Myc transactivation by the TATA binding protein in promoter-reporter assays.BMC biochemistry · 2005Article
- Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes.Molecular and cellular biology · 2005Article
- A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth.Molecular and cellular biology · 2000Article
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- The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation.Oncogene · 1999Review
- Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc.Oncogene · 1999Article
- c-Myc target genes involved in cell growth, apoptosis, and metabolism.Molecular and cellular biology · 1999Review
- Identification of a large Myc-binding protein that contains RCC1-like repeats.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene.Nucleic acids research · 1997Article
- Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins.Molecular and cellular biology · 1997Article
- The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter.Molecular and cellular biology · 1997Article
- YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A link between c-Myc-mediated transcriptional repression and neoplastic transformation.The Journal of clinical investigation · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The c-myc proto-oncogene encodes nuclear phosphoproteins that bind DNA in a sequence-specific fashion and appear to function as transcriptional activators. Here we demonstrate that a 40-kDa nuclear protein coimmunoprecipitated with c-Myc specifically when nuclear proteins, extracted from nuclei of exponentially growing murine B-lymphoma WEHI 231 cells by using procedures for preparation of trans-acting factors, were reacted with anti-c-Myc antibodies made against different regions of the c-Myc protein. In contrast, preparation of nuclear lysates under denaturing conditions significantly reduced this coprecipitation. Upon incubation of WEHI 231 cells with the reversible chemical cross-linking agent dithiobis(succinimidyl propionate), the 40-kDa protein could be cross-linked to c-Myc protein intracellularly. Identification of the 40-kDa protein as the TATA-binding protein (TBP) of the TFIID transcription initiation complex was made by comigration and V-8 protease mapping, which yielded identical peptide fragments upon digestion of the 40-kDa protein and material immunoprecipitated with an anti-TBP specific antibody. Furthermore, in vitro-translated TBP bound to the amino-terminal portion of c-Myc. Column chromatography of cross-linked nuclear proteins showed TBP to be in a large-molecular-weight complex with c-Myc, consistent with a transcription initiation complex. These results indicate that intracellularly, c-Myc interacts with TBP, suggesting a mechanism of interaction of this oncoprotein with the basal transcription machinery.
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Registered trials
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