ArticleJournal of virology1994
The bovine papillomavirus type 1 (BPV1) replication protein E1 modulates transcriptional activation by interacting with BPV1 E2.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo.Journal of virology · 2002Article
- Human TATA binding protein inhibits human papillomavirus type 11 DNA replication by antagonizing E1-E2 protein complex formation on the viral origin of replication.Journal of virology · 2002Article
- Article
- p53 protein is a suppressor of papillomavirus DNA amplificational replication.Journal of virology · 1998Article
- Characterization of the DNA-binding domain of the bovine papillomavirus replication initiator E1.Journal of virology · 1998Article
- Transient viral DNA replication and repression of viral transcription are supported by the C-terminal domain of the bovine papillomavirus type 1 E1 protein.Journal of virology · 1998Article
- Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions.Journal of virology · 1997Article
- Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins.Journal of virology · 1997Article
- Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis.The EMBO journal · 1997Article
- Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins.Journal of virology · 1997Article
- The initiator protein E1 binds to the bovine papillomavirus origin of replication as a trimeric ring-like structure.The EMBO journal · 1996Article
- Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.Journal of virology · 1996Article
- Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator.Journal of virology · 1996Article
- Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.The EMBO journal · 1995Article
- Control of HPV 18 DNA replication by cellular and viral transcription factors.Nucleic acids research · 1995Article
- Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB.Journal of virology · 1995Article
- E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats.Journal of virology · 1995Article
- The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID.Journal of virology · 1994Article
- The bovine papillomavirus E2 protein modulates the assembly of but is not stably maintained in a replication-competent multimeric E1-replication origin complex.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
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3 authors.
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Abstract
The study of bovine papillomavirus type 1 (BPV1) DNA replication has shown that E1 and E2 are the only viral proteins required for this process. Both E1 and E2 interact with the viral origin of replication (ori). The BPV1 E2 protein is also a well-characterized transcriptional regulator. We show in this report that E1 can modulate transcription by interactions with E2. At low concentrations, E1 enhanced the E2-mediated transactivation of heterologous promoters containing the BPV1 ori by promoting cooperative binding of both E1 and E2 to the DNA. In contrast, in the presence of excess E1, transactivation by E2 is repressed. This last process, however, does not require cooperative DNA binding of the two proteins. These results imply that the balance between these two distinct types of interaction is crucial both for control of replication and for early viral transcription.
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