ArticleImmunology1993
Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages.
Article in Immunology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
- Induction of killing of Mycobacterium avium subsp. hominissuis in macrophages by cytokine stimulated innate-like lymphoid cells is negatively affected by the pathogen.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Host-directed therapy to combat mycobacterial infections.Immunological reviews · 2021Review
- Subunit vaccine protects against a clinical isolate of Mycobacterium avium in wild type and immunocompromised mouse models.Scientific reports · 2021Article
- The Voltage-Dependent Anion Channels (VDAC) of Mycobacterium avium phagosome are associated with bacterial survival and lipid export in macrophages.Scientific reports · 2017Article
- Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis.Frontiers in microbiology · 2017Review
- Airway delivery of interferon-γ overexpressing macrophages confers resistance to Mycobacterium avium infection in SCID mice.Physiological reports · 2016Article
- Identification of virulence determinants of Mycobacterium avium that impact on the ability to resist host killing mechanisms.Journal of medical microbiology · 2010Article
- Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages.Infection and immunity · 2006Article
- Pathogenesis of Mycobacterium avium infection: typical responses to an atypical mycobacterium?Immunologic research · 2006Review
- Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics.Infection and immunity · 2005Article
- Phagosomal processing of Mycobacterium tuberculosis antigen 85B is modulated independently of mycobacterial viability and phagosome maturation.Infection and immunity · 2005Article
- Virulent Mycobacterium fortuitum restricts NO production by a gamma interferon-activated J774 cell line and phagosome-lysosome fusion.Infection and immunity · 2002Article
- Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways.Infection and immunity · 2002Article
- Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation.The Journal of experimental medicine · 2001Article
- Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase.Infection and immunity · 2001Article
- Immune deficiency presenting as mycobacterial infection.Clinical reviews in allergy & immunology · 2001Review
- Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.Infection and immunity · 2000Article
- In vitro T-cell activation of monocyte-derived macrophages by soluble messengers or cell-to-cell contact in bovine tuberculosis.Immunology · 2000Article
- Minor role played by type I tumour necrosis factor receptor in the control of Mycobacterium avium proliferation in infected mice.Immunology · 2000Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this study we found that addition of a range of doses of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha), or granulocyte-macrophage colony stimulating factor (GM-CSF) to cultures of bone marrow-derived murine macrophages infected with the 25291 strain of Mycobacterium avium gave rise to varying degrees of bacteriostasis. In contrast, similar treatment with interleukin-4 (IL-4) or IL-6 had no effect. However, when similar experiments with the former set of cytokines were performed using a panel of M. avium isolates, substantial isolate-to-isolate variation was observed. In cultures containing IFN-gamma, synthesis of substantial levels of reactive nitrogen intermediates was observed; however, neither these materials, nor reactive oxygen intermediates, were found to be responsible for observed bacteriostasis. In further experiments, in which the culture medium was supplemented with various concentrations of a weak acid or a weak base in order to influence the pH of macrophage intracellular compartments, it was found that the presence of the weak acid augmented the activity of IFN-gamma, whilst the weak base counteracted this effect. These data support the hypothesis, therefore, that the bacteriostatic effect of IFN-gamma against the growth of M. avium, rather than depending on reactive radical production, is mediated through acidification of the infected phagosome, perhaps through activation of proton pumps in the phagosomal membrane.
Indexed as
Identifiers
8288311PMC1422224W2396422387What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.