Evidence map›Paper›PMID 8285750›Full record

Trial reportArchives of disease in childhood1993

Enteral feeding of premature infants with Lactobacillus GG.

M R Millar, C Bacon, S L Smith, V Walker, M A Hall

Registry-linked trialOpen access · bronzeAbstract readClinical TrialComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00616876 (The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study), which is not on this map. Cited by 50 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 14 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00616876 phase2completednot on this mapstarted 2005, after this paper: background citation

The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants - A Pilot Study

TypeinterventionalSponsorBnai Zion Medical CenterRan2005 to 2007Enrolled28ConditionsNecrotizing Enterocolitis, SepsisArmsLactulose, Dextrose
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 14 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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  19. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 1997
    Trial
  20. Oral bacteriotherapy for viral gastroenteritis.Digestive diseases and sciences · 1994
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M R MillarDepartment of Microbiology, Royal Hampshire County Hospital, Winchester.
C Bacon
S L Smith
V Walker
M A Hall
Royal Hampshire County Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objectives of this study were to determine whether or not the probiotic Lactobacillus GG can colonise the immature bowel of premature infants and if so, does colonisation result in a reduction of the size of the bowel reservoir of nosocomial pathogens such as enterobacteriaceae, enterococci, yeasts or staphylococci, and does colonisation with Lactobacillus GG have any effect on the clinical progress and outcome. Twenty preterm infants with a gestational age of 33 weeks or less who were resident on a neonatal unit were studied from the initiation of milk feeds until discharge. The infants were randomised to receive either milk feeds or milk feeds supplemented with Lactobacillus GG 10(8) colony forming units twice a day for two weeks. The clinical features of the two groups of infants were similar. Orally administered Lactobacillus GG was well tolerated and did colonise the bowel of premature infants. However, colonisation with Lactobacillus GG did not reduce the faecal reservoir of potential pathogens and there was no evidence that colonisation had any positive clinical benefit for this particular group of infants.

Indexed as

Infant FoodBacteria, AnaerobicDouble-Blind MethodEnteral NutritionEnterobacteriaceaeEnterococcusFecesHumansInfant, NewbornInfant, PrematureIntestinesLacticaseibacillus caseiStaphylococcusTime Factors

Identifiers

PMID8285750
PMCPMC1029589
OpenAlexW1963588808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.