ArticleAntimicrobial agents and chemotherapy1993
Susceptibilities of Norwegian Candida albicans strains to fluconazole: emergence of resistance. The Norwegian Yeast Study Group.
Article in Antimicrobial agents and chemotherapy, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 85 citations in OpenAlex.
- Candidemia in Norway (1991 to 2003): results from a nationwide study.Journal of clinical microbiology · 2006Article
- Comparison of results obtained by testing with three different agar media and by the NCCLS M27-A method for in vitro testing of fluconazole against Candida spp.Journal of clinical microbiology · 2003Article
- In vitro and in vivo antifungal activities of TAK-456, a novel oral triazole with a broad antifungal spectrum.Antimicrobial agents and chemotherapy · 2002Article
- The ins and outs of DNA fingerprinting the infectious fungi.Clinical microbiology reviews · 2000Review
- Detection of fluconazole-resistant Candida strains by a disc diffusion screening test.Journal of clinical microbiology · 1999Article
- Fluconazole susceptibilities of bloodstream Candida sp. isolates as determined by National Committee for Clinical Laboratory Standards method M27-A and two other methods.Journal of clinical microbiology · 1999Article
- Constant low rate of fungemia in norway, 1991 to 1996. The Norwegian Yeast Study Group.Journal of clinical microbiology · 1998Article
- Efficacy of D0870 treatment of experimental Candida vaginitis.Antimicrobial agents and chemotherapy · 1997Article
- Antifungal prophylaxis during neutropenia and immunodeficiency.Clinical microbiology reviews · 1997Review
- Review article: the therapy of gastrointestinal infections associated with the acquired immunodeficiency syndrome.Alimentary pharmacology & therapeutics · 1997Review
- Azole resistance in Candida.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Review
- Mixed oropharyngeal candidiasis due to Candida albicans and non-albicans Candida strains in HIV-infected patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1996Article
- Typing Candida albicans oral isolates from human immunodeficiency virus-infected patients by multilocus enzyme electrophoresis and DNA fingerprinting.Journal of clinical microbiology · 1996Article
- Variation in fluconazole efficacy for Candida albicans strains sequentially isolated from oral cavities of patients with AIDS in an experimental murine candidiasis model.Antimicrobial agents and chemotherapy · 1996Article
- Susceptibility testing of fungi: current status of correlation of in vitro data with clinical outcome.Journal of clinical microbiology · 1996Review
- Susceptibilities of Candida spp. to antifungal agents visualized by two-dimensional scatterplots of relative growth.Antimicrobial agents and chemotherapy · 1996Article
- Physiological traits associated with success of Candida albicans strains as commensal colonizers and pathogens.Journal of clinical microbiology · 1995Article
- Antifungal susceptibility testing of yeasts: evaluation of technical variables for test automation.Antimicrobial agents and chemotherapy · 1995Article
- Patterns of in vitro activity of itraconazole and imidazole antifungal agents against Candida albicans with decreased susceptibility to fluconazole from Spain.Antimicrobial agents and chemotherapy · 1995Article
- Antifungal agents in neonatal systemic candidiasis.Antimicrobial agents and chemotherapy · 1995Review
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3 authors.
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Abstract
All Candida albicans isolates in Norwegian microbiological laboratories in 1991 judged clinically important (except vaginal isolates) were collected. The isolates were tested for susceptibility to fluconazole with an agar dilution test and a commercially available agar diffusion test. A total of 212 strains (95%) were susceptible to fluconazole, and MICs for most of the strains (92%) were < or = 1.56 micrograms/ml. The agar diffusion test using a 15-micrograms tablet and a 48-h incubation period separated resistant from susceptible strains with a wide margin. The only exception was a strain for which the MIC was 6.25 micrograms/ml. The difference in zone size between the resistant and the susceptible populations of strains was 11 mm. Accordingly, it appears that the agar diffusion test is an appropriate method for detecting fluconazole resistance. The 12 fluconazole-resistant isolates originated from eight AIDS patients with oral or esophageal Candida infections. Seven of the patients had been given fluconazole for 1 month or more, often as self medication. Four had infections that were clinically resistant to fluconazole; one additional patient responded only when the dose was increased. All isolates recovered from these patients were analyzed by multilocus enzyme electrophoresis. The 12 C. albicans isolates belonged to five electrophoretic types, but three of four patients attending one hospital had isolates belonging to one electrophoretic type. One possible explanation for this finding could be that a nosocomial spread of resistant strains has occurred.
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