ArticleThe Journal of clinical investigation1994
Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
- Preventing mitochondrial reverse electron transport as a strategy for cardioprotection.Basic research in cardiology · 2023Review
- Metabolite signaling in the heart.Nature cardiovascular research · 2023Review
- Hidden Pool of Cardiac Adenine Nucleotides That Controls Adenosine Production.Pharmaceuticals (Basel, Switzerland) · 2023Article
- CardiacHeart failure reviews · 2023Review
- LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway.Basic research in cardiology · 2021Article
- Local translation in nuclear condensate amyloid bodies.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A translational program that suppresses metabolism to shield the genome.Nature communications · 2020Article
- Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury.Redox biology · 2020Article
- Tissue acidosis does not mediate the hypoxia selectivity of [Scientific reports · 2019Article
- Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.Nature communications · 2017Article
- The Role of Adenosine Signaling in Headache: A Review.Brain sciences · 2017Review
- Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.The Journal of biological chemistry · 2011Article
- Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.Journal of molecular and cellular cardiology · 2010Article
- Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.Molecular and cellular biology · 2009Article
- Energy metabolism in heart failure and remodelling.Cardiovascular research · 2009Review
- Energetic metabolism during acute stretch-related atrial fibrillation.Molecular and cellular biochemistry · 2008Article
- A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes.Biophysical journal · 2006Article
- Induction of cell surface blebbing by increased cellular Pi concentration.The Biochemical journal · 1996Article
- Oxidative modulation and inactivation of rabbit cardiac adenylate deaminase.The Biochemical journal · 1995Article
- Metabolic reserve of the heart: the forgotten link between contraction and coronary flow.Progress in cardiovascular diseasesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Capacity for ATP resynthesis during recovery from ischemia or hypoxia is limited to the size of the adenine nucleotide pool, which is determined in part by the activity of cytosolic 5'-nucleotidase (5'-NT): AMP-->adenosine plus inorganic phosphate (Pi). To define in vivo regulation of 5'-NT, we used the tools of 31P nuclear magnetic resonance (NMR), spectroscopy and chemical assay to measure the substrates (AMP), products (Pi, adenosine, and its catabolites), and inhibitors (Pi and H+) of 5'-NT in isolated perfused rat hearts exposed to hypoxia (where pH remains near 7) and no flow, global ischemia (where pH falls to 6.1). We estimated 5'-NT reaction velocity, assessed the relative contributions of Pi and H+ to enzyme inhibition, and defined the consequences of changes in 5'-NT activity on ATP resynthesis after hypoxia and ischemia. We conclude that (a) 5'-NT is activated during hypoxia and early ischemia but is inhibited during prolonged ischemia, (b) H+ (pH < 6.2) is a potent inhibitor of 5'-NT, and (c) differences in AMP accumulation are sufficient to explain the differences in the capacity for net ATP resynthesis in ischemic and hypoxic tissue. These observations have implications for our understanding of heterogeneity of ischemic injury and myocardial protection during ischemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.