ArticleThe Journal of clinical investigation1994
Linkage of azurophil granule secretion in neutrophils to chloride ion transport and endosomal transcytosis.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Glycine induces enhancement of bactericidal activity of neutrophils.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Article
- Synthesis, Biological Evaluation, and Molecular Modeling of Aza-Crown Ethers.Molecules (Basel, Switzerland) · 2021Article
- Frontline Science: Pathological conditioning of human neutrophils recruited to the airway milieu in cystic fibrosis.Journal of leukocyte biology · 2018Article
- The Ontogeny of a Neutrophil: Mechanisms of Granulopoiesis and Homeostasis.Microbiology and molecular biology reviews : MMBR · 2018Review
- The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.Mucosal immunology · 2016Article
- The pore-forming toxin listeriolysin O is degraded by neutrophil metalloproteinase-8 and fails to mediate Listeria monocytogenes intracellular survival in neutrophils.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway.Free radical biology & medicine · 2013Article
- Counterregulation of clathrin-mediated endocytosis by the actin and microtubular cytoskeleton in human neutrophils.American journal of physiology. Cell physiology · 2009Article
- Functional analysis of monocyte MHC class II compartments.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Neutrophil elastase, an acid-independent serine protease, facilitates reovirus uncoating and infection in U937 promonocyte cells.Virology journal · 2005Article
- Identification and subcellular localization of neuronal calcium sensor-1 (NCS-1) in human neutrophils and HL-60 cells.Inflammation · 2003Article
- A new assay to monitor the degranulation process in phagocytizing human neutrophils.Inflammation · 2002Article
- Mucosal mast cell secretion processes imaged using three-photon microscopy of 5-hydroxytryptamine autofluorescence.Biophysical journal · 1999Article
- Chloride ion efflux regulates adherence, spreading, and respiratory burst of neutrophils stimulated by tumor necrosis factor-alpha (TNF) on biologic surfaces.The Journal of cell biology · 1996Article
- The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation.The Biochemical journal · 1995Article
- Cellular chloride depletion inhibits cAMP-activated electrogenic chloride fluxes in HT29-18-C1 cells.The Journal of membrane biology · 1995Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils contain at least two types of secretory granules. The present work links the secretion of the (lysosomal type) azurophil granules, but not that of specific granules, to endosomal transport mechanisms. (a) Selective stimulation of azurophil granule secretion by the Na-ionophore Monensin, or nonselective stimulation by FMLP after cytochalasin B pretreatment elicited marked pinocytic activity in parallel with azurophil granule release, whereas FMLP alone, selective for specific granules, elicited little fluid pinocytosis. (b) Pinosomes thus formed fused with azurophil granules, suggesting that exocytosis of azurophil granules might occur via endosomal organelles. This hypothesis was tested by determining the effect on the endosomal pathway(s) of two treatments that selectively prevent the release of azurophil granule contents without interfering with specific granule secretion, namely replacement of Cl- with gluconate- or the addition of zinc. Replacement of Cl- was found to impair the pinocytosis process itself, whereas ZnSO4 appeared to prevent the fusion between endosomes and azurophil granules. These data support the concept that the (lysosomal type) azurophil granules, but not the specific granules, are secreted through the endosomal pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.