ReviewCancer metastasis reviews1993
Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer.
Review in Cancer metastasis reviews, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 123 citations in OpenAlex.
- Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies.Frontiers in genetics · 2023Review
- Epiregulin expression and secretion is increased in castration-resistant prostate cancer.Frontiers in oncology · 2023Article
- Peri-Prostatic Adipocyte-Released TGFβ Enhances Prostate Cancer Cell Motility by Upregulation of Connective Tissue Growth Factor.Biomedicines · 2021Article
- Alterations in TGFβ signaling during prostate cancer progression.American journal of clinical and experimental urology · 2021Review
- JunD Is Required for Proliferation of Prostate Cancer Cells and Plays a Role in Transforming Growth Factor-β (TGF-β)-induced Inhibition of Cell Proliferation.The Journal of biological chemistry · 2016Article
- Role of proprotein convertases in prostate cancer progression.Neoplasia (New York, N.Y.) · 2012Article
- Discovery of novel fibroblast growth factor receptor 1 kinase inhibitors by structure-based virtual screening.Journal of medicinal chemistry · 2010Article
- Cannabinoids and cancer: pros and cons of an antitumour strategy.British journal of pharmacology · 2006Review
- Molecular pathology of prostate cancer.Journal of clinical pathology · 2005Review
- Perlecan knockdown in metastatic prostate cancer cells reduces heparin-binding growth factor responses in vitro and tumor growth in vivo.Clinical & experimental metastasis · 2005Article
- Review
- Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies.British journal of cancer · 1998Article
- Isolation and characterization of invasive and noninvasive variants of a rat bladder tumor cell line.Japanese journal of cancer research : Gann · 1997Article
- Differential regulation of the mitogen-activated protein and stress-activated protein kinase cascades by adrenergic agonists in quiescent and regenerating adult rat hepatocytes.Molecular and cellular biology · 1997Article
- Molecular biology of prostate cancer.World journal of urology · 1996Review
- Cytokines in tumour growth, migration and metastasis.World journal of urology · 1996Review
- In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signals.Clinical & experimental metastasis · 1995Article
- Epidermal growth factor receptor content in rat prostatic adenocarcinoma: effects of endocrine treatment.Urological research · 1995Article
- Regulation of prostate growth by fibroblast growth factors.World journal of urology · 1995Review
- Prostate cancer progression. Implications of histopathology.The American journal of pathology · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Prostate adenocarcinoma, the most common tumor occurring among North American men, preferentially metastasizes to bone, where it characteristically forms osteoblastic lesions. The following growth regulatory factors are expressed in some human prostate cancers and/or established cell lines: epidermal growth factor (EGF), transforming growth factor alpha, transforming growth factor beta, basic fibroblast growth factor (bFGF), and insulin-like growth factor. Some of these, especially EGF, bFGF, and TGF-beta, are also implicated in growth regulation in normal and benign hyperplastic prostates. Although evidence from in vitro study of the small number of prostate cell lines available demonstrates that these growth regulatory pathways are exploited by some of these cells, direct in vivo evidence is limited. The development of human prostate cancer cell lines which grow and metastasize in immune-deficient rodents is an advance which now permits experimental analysis of the role of these growth factors in prostatic metastasis, particularly to bone. The progression and metastasis of human prostate cancer results from the complex interactions of multiple growth factors, androgens, and cellular communication, which form a dynamic network. Continued progress in the study and treatment of this disease will require new conceptual frameworks as well as successful application of the techniques of molecular and cellular biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.