ArticleAntonie van Leeuwenhoek1993
Control and regulation of metabolic fluxes in microbes by substrates and enzymes.
Article in Antonie van Leeuwenhoek, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 14 citations in OpenAlex.
- Nutrient-limited microbial growth kinetics: overview and recent advances.Antonie van Leeuwenhoek · 1993Review
- Carbohydrate transport in bacteria under environmental conditions, a black box?Antonie van Leeuwenhoek · 1993Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
The control of enzymes and substrates on the flux through microbial metabolic pathways can be quantified in terms of flux control coefficients. In pathways involving group transfer, the summation theorem for flux control by the enzymes has to be modified: the sum of control by all enzymes is between 1 and 2. The phosphoenolpyruvate:glucose phosphotransferase system is such a pathway. Experimental determination of the control by the enzymes in this pathway is under way. The control of the enzymes on the glycolytic flux in yeast is low, with the possible exception of the uptake step. In Klebsiella pneumoniae potassium and ammonium ions can simultaneously be 'limiting', (i.e. have significant control on growth) at pH6, but not at pH8. This may be due to the fact that at pH8 the high-affinity potassium uptake system is absent.
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