ReviewAntonie van Leeuwenhoek1993
Nutrient-limited microbial growth kinetics: overview and recent advances.
Review in Antonie van Leeuwenhoek, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Single-cell quantification reveals divergent mixotrophic strategies underlying niche partitioning in marineScience advances · 2026Article
- Mitochondrial localization of key NADApplied and environmental microbiology · 2026Article
- Microbial interaction networks as climate thermometers: redefining temperature sensitivity of aerobic methanotrophy in freshwater ecosystems.npj biodiversity · 2026Article
- Physiological basis for atmospheric methane oxidation and methanotrophic growth on air.Nature communications · 2024Article
- Article
- Multisubstrate DNA stable isotope probing reveals guild structure of bacteria that mediate soil carbon cycling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Investment in secreted enzymes during nutrient-limited growth is utility dependent.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Complementary Metaproteomic Approaches to Assess the Bacterioplankton Response toward a Phytoplankton Spring Bloom in the Southern North Sea.Frontiers in microbiology · 2017Article
- A mesoscopic stochastic model for the specific consumption rate in substrate-limited microbial growth.PloS one · 2017Article
- Replacement of the initial steps of ethanol metabolism in Saccharomyces cerevisiae by ATP-independent acetylating acetaldehyde dehydrogenase.FEMS yeast research · 2016Article
- Carbon Availability Modifies Temperature Responses of Heterotrophic Microbial Respiration, Carbon Uptake Affinity, and Stable Carbon Isotope Discrimination.Frontiers in microbiology · 2016Article
- A model of extracellular enzymes in free-living microbes: which strategy pays off?Applied and environmental microbiology · 2015Article
- Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis.BMC microbiology · 2014Article
- Plant soil interactions alter carbon cycling in an upland grassland soil.Frontiers in microbiology · 2013Article
- Two isozymes of particulate methane monooxygenase with different methane oxidation kinetics are found in Methylocystis sp. strain SC2.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Dilution-to-extinction culturing of psychrotolerant planktonic bacteria from permanently ice-covered lakes in the McMurdo Dry Valleys, Antarctica.Microbial ecology · 2008Article
- Multiphasic kinetics of transformation of 1,2,4-trichlorobenzene at nano- and micromolar concentrations by Burkholderia sp. strain PS14.Applied and environmental microbiology · 2001Article
- Temperature dependence of inorganic nitrogen uptake: reduced affinity for nitrate at suboptimal temperatures in both algae and bacteria.Applied and environmental microbiology · 1999Article
- Growth kinetics of suspended microbial cells: from single-substrate-controlled growth to mixed-substrate kinetics.Microbiology and molecular biology reviews : MMBR · 1998Review
- Microbial physiology and ecology of slow growth.Microbiology and molecular biology reviews : MMBR · 1997Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional concepts of nutrient uptake and growth kinetics as linked by cell yield are presented. Phenomena affecting the kinetics are examined along with a discussion of those which lead to ambiguity. Concepts of flux control are presented to help understand the distribution of material along metabolic pathways. Specific affinity is described to relate nutrient accumulation rates to transporter density. It is shown to be a primary kinetic constant and the best available index of nutrient collection ability. As an aid to understanding, specific affinity is reexpressed in terms of membrane permeability. Formulations of nutrient transport rate as a function of cellular composition, particularly transporter and enzyme content and known as janusian kinetics, are described as an improvement to specific affinity theory. Procedures for quantified unidirectional fluxes are reviewed to identify the difference between gross and net transport rates of substrate. Collision frequency theory is used to show that in addition to total biomass, cell size and transporter density should also be included in rate equations describing microbial growth. Theory diversity suggests that one reason for microbial metabolic is that the likelihood of additional collisions of substrate molecules with a cell surface, after an initial collision, requires only a sparse distribution of transporter sites for maximal rate, leaving room for additional transporters able to collect other substrate types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.