ArticleProceedings of the National Academy of Sciences of the United States of America1994
Isolation and characterization of major histocompatibility complex class IIB genes from the nurse shark.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 102 citations in OpenAlex.
- Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula).Scientific reports · 2023Article
- Discovery of an ancient MHC category with both class I and class II features.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between βJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Cartilaginous fish class II genes reveal unprecedented old allelic lineages and confirm the late evolutionary emergence of DM.Molecular immunology · 2020Article
- Ancient Use of Ig Variable Domains Contributes Significantly to the TCRδ Repertoire.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Review
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Comparative genome analyses reveal distinct structure in the saltwater crocodile MHC.PloS one · 2014Article
- Molecular cloning and expression analysis of major histocompatibility complex class IIB gene of the Whitespotted bambooshark (Chiloscyllium plagiosum).Fish physiology and biochemistry · 2013Article
- Patterns of variation of the major histocompatibility complex class IIB loci in Chinese goose (Anser Cygnoides).Immunogenetics · 2009Article
- Elasmobranch immune cells as a source of novel tumor cell inhibitors: Implications for public health.Integrative and comparative biology · 2006Article
- Major histocompatibility class II genes in rainbow trout (Oncorhynchus mykiss) exhibit temperature dependent downregulation.Immunogenetics · 2006Article
- Construction of a nurse shark (Ginglymostoma cirratum) bacterial artificial chromosome (BAC) library and a preliminary genome survey.BMC genomics · 2006Article
- Reconstructing immune phylogeny: new perspectives.Nature reviews. Immunology · 2005Review
- Comparative genomics of major histocompatibility complexes.Immunogenetics · 2005Review
- Characterization of a divergent non-classical MHC class I gene in sharks.Immunogenetics · 2003Article
- Primitive synteny of vertebrate major histocompatibility complex class I and class II genes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes.Genetics · 1998Article
- Identification and characterization of a new major histocompatibility complex class I gene in carp (Cyprinus carpio L.).Immunogenetics · 1996Article
- Molecular cloning and linkage analysis of the Japanese medaka fish complement Bf/C2 gene.Immunogenetics · 1996Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The major histocompatibility complex (MHC) contains a set of linked genes which encode cell surface proteins involved in the binding of small peptide antigens for their subsequent recognition by T lymphocytes. MHC proteins share structural features and the presence and location of polymorphic residues which play a role in the binding of antigens. In order to compare the structure of these molecules and gain insights into their evolution, we have isolated two MHC class IIB genes from the nurse shark, Ginglymostoma cirratum. Two clones, most probably alleles, encode proteins which differ by 13 amino acids located in the putative antigen-binding cleft. The protein structure and the location of polymorphic residues are similar to their mammalian counterparts. Although these genes appear to encode a typical MHC protein, no T-cell-mediated responses have been demonstrated in cartilaginous fish. The nurse shark represents the most phylogenetically primitive organism in which both class IIA [Kasahara, M., Vazquez, M., Sato, K., McKinney, E.C. & Flajnik, M.F. (1992) Proc. Natl. Acad. Sci USA 89, 6688-6692] and class IIB genes, presumably encoding the alpha/beta heterodimer, have been isolated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.