ArticleNaunyn-Schmiedeberg's archives of pharmacology1993
ATP and endogenous agonists inhibit evoked [3H]-noradrenaline release in rat iris via A1 and P2y-like purinoceptors.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Purinergic signalling in the urinary tract in health and disease.Purinergic signalling · 2014Review
- P2 receptor-mediated modulation of neurotransmitter release-an update.Purinergic signalling · 2007Article
- Immunolocalisation of P2Y receptors in the rat eye.Purinergic signalling · 2004Article
- 3H-Noradrenaline release from mouse iris-ciliary body: role of presynaptic muscarinic heteroreceptors.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- An interaction between ATP and high K+: mutual impairment of ATP- and high K(+)-evoked [Ca2+]i increase in NG 108-15 cells.Neurochemical research · 2002Article
- P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Purinoceptor modulation of noradrenaline release in rat tail artery: tonic modulation mediated by inhibitory P2Y- and facilitatory A2A-purinoceptors.British journal of pharmacology · 1996Article
- Cultured chick sympathetic neurons: modulation of electrically evoked noradrenaline release by P2-purinoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Cross talk between receptors mediating contraction and relaxation in the arterioles but not the dilator muscle of the rat iris.British journal of pharmacology · 1995Article
- P2-purinoceptor-mediated inhibition of noradrenaline release in rat atria.British journal of pharmacology · 1995Article
- Two relaxation-mediating P2-purinoceptors in guinea-pig taenia caeci.Naunyn-Schmiedeberg's archives of pharmacology · 1995Article
- Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Evidence for P2-purinoceptor-mediated inhibition of noradrenaline release in rat brain cortex.British journal of pharmacology · 1994Article
- Blockade of P2X-purinoceptors by trypan blue in rat vas deferens.British journal of pharmacology · 1994Article
- Blockade by 4,4'-diisothiocyanatostilbene-2,2'-disulphonate (DIDS) of P2X-purinoceptors in rat vas deferens.British journal of pharmacology · 1994Article
- P2-purinoceptor-mediated autoinhibition of sympathetic transmitter release in mouse and rat vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1994Article
- Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1993Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of ATP, adenosine and purinoceptor antagonists on field stimulation-evoked (3 Hz, 2 min) [3H]-noradrenaline overflow were investigated in the rat isolated iris. ATP and adenosine inhibited the evoked overflow of [3H]-noradrenaline. 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) shifted the concentration-response curve of ATP to the right in a concentration-dependent manner, but with a potency (-log KB = 7.88) much lower than expected for an A1 adenosine receptor. In the continuous presence of DPCPX, the ATP-induced prejunctional inhibition was unaffected by suramin (100 mumol/l) and DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, 50 mumol/l) but was antagonized by the P2Y-receptor antagonist cibacron blue (= reactive blue 2; 30 and 100 mumol/l, -log KB = 4.7) and alpha,beta-methylene-ATP (10 mumol/l). Whereas the evoked [3H]-noradrenaline overflow was unaffected by suramin and DIDS, cibacron blue and alpha,beta-methylene-ATP caused a small and transient increase. Cibacron blue at 30 mumol/l failed to antagonize the inhibition of evoked [3H]-noradrenaline overflow that adenosine produced in the absence of DPCPX. Basal [3H]-noradrenaline overflow was enhanced by cibacron blue, not changed by alpha,beta-methylene-ATP and DIDS, and decreased by suramin. The results show that exogenous ATP inhibits sympathetic neurotransmission in the rat iris via A1 and P2Y-like purinoceptors. The latter have a low apparent affinity for cibacron blue and probably are blocked by alpha,beta-methylene-ATP. Under the present conditions, endogenous purines exert a tonic inhibition not only via A1- but also via these P2Y-receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.