ArticleThe Journal of cell biology1993
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion.
Article in The Journal of cell biology, 1993. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 244 citations in OpenAlex.
- Rho/ROCK signaling and α-catenin mediate β-catenin-driven hyperplasia in the adrenal cortex via adherens junctions.The Journal of clinical investigation · 2026Article
- The Notch signaling pathway in skeletal muscle health and disease.Muscle & nerve · 2022Review
- Desmosomes as Signaling Hubs in the Regulation of Cell Behavior.Frontiers in cell and developmental biology · 2021Review
- Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.Oncotarget · 2017Review
- Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells.Frontiers in cellular neuroscience · 2017Article
- The Integrated Role of Wnt/β-Catenin, N-Glycosylation, and E-Cadherin-Mediated Adhesion in Network Dynamics.PLoS computational biology · 2016Article
- Wnt signaling and the control of human stem cell fate.Stem cell reviews and reports · 2014Review
- Looking beyond the Wnt pathway for the deep nature of β-catenin.EMBO reports · 2013Review
- γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.Leukemia · 2013Article
- Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion.Journal of cell science · 2013Article
- Plakoglobin: role in tumorigenesis and metastasis.International journal of cell biology · 2012Article
- Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.Cold Spring Harbor perspectives in biology · 2009Review
- Anchoring junctions as drug targets: role in contraceptive development.Pharmacological reviews · 2008Review
- WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer.Molecular biology of the cell · 2007Article
- Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells.Experimental cell research · 2007Article
- Wingless signaling modulates cadherin-mediated cell adhesion in Drosophila imaginal disc cells.Journal of cell science · 2006Article
- Inhibited neurogenesis in JNK1-deficient embryonic stem cells.Molecular and cellular biology · 2005Article
- Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes.The Journal of cell biology · 2004Article
- beta-catenin-dependent and -independent effects of DeltaN-plakoglobin on epidermal growth and differentiation.Molecular and cellular biology · 2004Article
- Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks.Molecular psychiatry · 2003Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Wnt-1 gene plays an essential role in fetal brain development and encodes a secreted protein whose signaling mechanism is presently unknown. In this report we have investigated intracellular mechanisms by which the Wnt-1 gene induces morphological changes in PC12 pheochromocytoma cells. PC12 cells expressing Wnt-1 show increased steady-state levels of the adhesive junction protein plakoglobin, and an altered distribution of this protein within the cell. This effect appears similar to a modulation of the plakoglobin homolog, Armadillo, that occurs in Drosophila embryos in response to the Wnt-1 homolog, wingless (Riggleman, B., P. Schedl, and E. Wieschaus. 1990. Cell. 63:549-560). In addition, PC12/Wnt-1 cells show elevated expression of E-cadherin and increased calcium-dependent cell-cell adhesion. These results imply evolutionary conservation of cellular responses to Wnt-1/wingless and indicate that in certain cell types Wnt-1 may act to modulate cell adhesion mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.